Papers/PMID:41798953
Impact of creatine supplementation on inflammation: evidence from a systematic review and meta-analysis of randomized double-blind placebo trials.
Frontiers in immunology2026The record
2 findings drawn from this paper, on 1 compound across 2 endpoints, 2 of them null.
What it reported
How to read these marksEvery finding here is a null result.
What did not
2 findings
creatine — no detected effect on C-reactive protein concentration
LikelyGrade B, Likely. Human evidence, limited replication or design limits.FindingNull result“Pooled analysis showed no significant acute effects of creatine on CRP (SMD = 0.32; 95% CI: -0.29 to 0.94; p = 0.30; I² = 28%).”
Quoted verbatim from Impact of creatine supplementation on inflammation: evidence from a systematic review and meta-analysis of randomized double-blind placebo trials.. - Study
- meta-analysis
- Population
- healthy individuals, athletes and clinical populations
Impact of creatine supplementation on inflammation: evidence from a systematic review and meta-analysis of randomized double-blind placebo trials.2026PMID:41798953
creatine — no detected effect on interleukin-6 concentration
SuggestiveGrade C, Suggestive. Weak human evidence, or strong evidence in a mismatched population.FindingNull result“Chronic effects of creatine on CRP (SMD = -0.11; 95% CI: -0.69 to 0.48; p = 0.73; I² = 0%) and IL-6 (SMD = -0.06; 95% CI: -0.64 to 0.53; p = 0.84; I² = 0%) were also no significant.”
Quoted verbatim from Impact of creatine supplementation on inflammation: evidence from a systematic review and meta-analysis of randomized double-blind placebo trials.. - Study
- meta-analysis
- Population
- healthy individuals, athletes and clinical populations
Impact of creatine supplementation on inflammation: evidence from a systematic review and meta-analysis of randomized double-blind placebo trials.2026PMID:41798953