Papers/PMID:39632602
Crocin Supplementation on Inflammation and Oxidative Stress: A Systematic Review and Meta-Analysis.
Phytotherapy research : PTR2025The record
5 findings · 1 compound · 5 endpoints · 1 null
What it reported
How to read these marksWhat moved
4 findings
crocin-1 — increases total antioxidant capacity
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Also, crocin supplementation led to a significant increase in total antioxidant capacity (TAC) (SMD: 1.48; 95%CI: 0.52 to 2.43; p = 0.002).”
Quoted verbatim from Crocin Supplementation on Inflammation and Oxidative Stress: A Systematic Review and Meta-Analysis.. - Study
- meta-analysis
- Population
- Adults supplemented with crocin in pooled randomised clinical trials
Effect 1.48 standardised mean difference, 95% CI 0.52 to 2.43
Crocin Supplementation on Inflammation and Oxidative Stress: A Systematic Review and Meta-Analysis.2025PMID:39632602Permalink
crocin-1 — decreases C-reactive protein concentration
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×1“Our findings indicated that crocin supplementation significantly reduced c-reactive protein (CRP) levels (SMD: -0.50; 95%CI: -0.86 to -0.13; p = 0.008), tumor necrosis factor-α (TNF-α) (SMD: -1.96; 95%CI: -2.72 to -1.19; p < 0.001), and interleukin-6 (IL-6) (SMD: -3.52; 95%CI: -6.84 to -0.20; p = 0.03).”
Quoted verbatim from Crocin Supplementation on Inflammation and Oxidative Stress: A Systematic Review and Meta-Analysis.. - Study
- meta-analysis
- Population
- Adults supplemented with crocin in pooled randomised clinical trials
Effect -0.5 standardised mean difference, 95% CI -0.86 to -0.13
Crocin Supplementation on Inflammation and Oxidative Stress: A Systematic Review and Meta-Analysis.2025PMID:39632602Permalink
crocin-1 — decreases tumour necrosis factor alpha concentration
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Our findings indicated that crocin supplementation significantly reduced c-reactive protein (CRP) levels (SMD: -0.50; 95%CI: -0.86 to -0.13; p = 0.008), tumor necrosis factor-α (TNF-α) (SMD: -1.96; 95%CI: -2.72 to -1.19; p < 0.001), and interleukin-6 (IL-6) (SMD: -3.52; 95%CI: -6.84 to -0.20; p = 0.03).”
Quoted verbatim from Crocin Supplementation on Inflammation and Oxidative Stress: A Systematic Review and Meta-Analysis.. - Study
- meta-analysis
- Population
- Adults supplemented with crocin in pooled randomised clinical trials
Effect -1.96 standardised mean difference, 95% CI -2.72 to -1.19
Crocin Supplementation on Inflammation and Oxidative Stress: A Systematic Review and Meta-Analysis.2025PMID:39632602Permalink
crocin-1 — decreases interleukin-6 concentration
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Our findings indicated that crocin supplementation significantly reduced c-reactive protein (CRP) levels (SMD: -0.50; 95%CI: -0.86 to -0.13; p = 0.008), tumor necrosis factor-α (TNF-α) (SMD: -1.96; 95%CI: -2.72 to -1.19; p < 0.001), and interleukin-6 (IL-6) (SMD: -3.52; 95%CI: -6.84 to -0.20; p = 0.03).”
Quoted verbatim from Crocin Supplementation on Inflammation and Oxidative Stress: A Systematic Review and Meta-Analysis.. - Study
- meta-analysis
- Population
- Adults supplemented with crocin in pooled randomised clinical trials
Effect -3.52 standardised mean difference, 95% CI -6.84 to -0.2
Crocin Supplementation on Inflammation and Oxidative Stress: A Systematic Review and Meta-Analysis.2025PMID:39632602Permalink
What did not
1 finding
crocin-1 — no detected effect on malondialdehyde (circulating)
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“Overall effect size showed that crocin intake failed to change the erythrocyte sedimentation rate (ESR) and malondialdehyde (MDA) levels significantly.”
Quoted verbatim from Crocin Supplementation on Inflammation and Oxidative Stress: A Systematic Review and Meta-Analysis.. - Study
- meta-analysis
- Population
- Adults supplemented with crocin in pooled randomised clinical trials
Crocin Supplementation on Inflammation and Oxidative Stress: A Systematic Review and Meta-Analysis.2025PMID:39632602Permalink