Papers/PMID:38431600
Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.
Trials2024The record
10 findings · 1 compound · 10 endpoints · 10 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
10 findings
coenzyme Q10 — no detected effect on C-reactive protein concentration
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull resultreplicated ×1“The differences in the CRP and ESR levels were not significant between CoQ10 and placebo groups (P = 0.550 and P = 0.306, respectively) (Table 2).”
Quoted verbatim from Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.. - Study
- RCT
- Participants
- 52
- Duration
- 10 days
- Dose
- 100 mg three times a day after meals, total 300 mg/day
- Population
- Adults aged 18-65 with 20-60% total body surface area burns admitted to a burn ICU in Isfahan, Iran, all receiving routine burn care and the unit's standard vitamin, selenium, zinc and B-complex supplementation in both arms; primary outcome.
Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.2024PMID:38431600Permalink
coenzyme Q10 — no detected effect on malondialdehyde (circulating)
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“As shown in Table 2, the between-group comparison revealed no significant difference between CoQ10 and placebo groups at the end of the study for MDA (P = 0.692), SOD activity (P = 0.633), and TAC (P = 0.865).”
Quoted verbatim from Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.. - Study
- RCT
- Participants
- 52
- Duration
- 10 days
- Dose
- 100 mg three times a day after meals, total 300 mg/day
- Population
- Adults aged 18-65 with 20-60% total body surface area burns admitted to a burn ICU in Isfahan, Iran, all receiving routine burn care and the unit's standard vitamin, selenium, zinc and B-complex supplementation in both arms; primary outcome.
Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.2024PMID:38431600Permalink
coenzyme Q10 — no detected effect on blood haemoglobin concentration
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“As shown in Table 2, there were no significant differences in hematological parameters (RBC, hemoglobin, hematocrit, MCV, MCH, MCHC, WBC, lymphocyte, neutrophil, and platelet) between CoQ10 and placebo groups at the end of the study (P > 0.05).”
Quoted verbatim from Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.. - Study
- RCT
- Participants
- 52
- Duration
- 10 days
- Dose
- 100 mg three times a day after meals, total 300 mg/day
- Population
- Adults aged 18-65 with 20-60% total body surface area burns admitted to a burn ICU in Isfahan, Iran, all receiving routine burn care and the unit's standard vitamin, selenium, zinc and B-complex supplementation in both arms; secondary outcome.
Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.2024PMID:38431600Permalink
coenzyme Q10 — no detected effect on total leukocyte count
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“As shown in Table 2, there were no significant differences in hematological parameters (RBC, hemoglobin, hematocrit, MCV, MCH, MCHC, WBC, lymphocyte, neutrophil, and platelet) between CoQ10 and placebo groups at the end of the study (P > 0.05).”
Quoted verbatim from Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.. - Study
- RCT
- Participants
- 52
- Duration
- 10 days
- Dose
- 100 mg three times a day after meals, total 300 mg/day
- Population
- Adults aged 18-65 with 20-60% total body surface area burns admitted to a burn ICU in Isfahan, Iran, all receiving routine burn care and the unit's standard vitamin, selenium, zinc and B-complex supplementation in both arms; primary outcome.
Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.2024PMID:38431600Permalink
coenzyme Q10 — no detected effect on all-cause mortality
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“Moreover, no significant difference was observed in the 28-day mortality rate between the two groups (2 in the CoQ10 group vs. 3 in the placebo group) (P = 0.99).”
Quoted verbatim from Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.. - Study
- RCT
- Participants
- 52
- Duration
- 10 days
- Dose
- 100 mg three times a day after meals, total 300 mg/day
- Population
- Adults aged 18-65 with 20-60% total body surface area burns admitted to a burn ICU in Isfahan, Iran, all receiving routine burn care and the unit's standard vitamin, selenium, zinc and B-complex supplementation in both arms; secondary outcome.
Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.2024PMID:38431600Permalink
coenzyme Q10 — no detected effect on haematocrit
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“As shown in Table 2, there were no significant differences in hematological parameters (RBC, hemoglobin, hematocrit, MCV, MCH, MCHC, WBC, lymphocyte, neutrophil, and platelet) between CoQ10 and placebo groups at the end of the study (P > 0.05).”
Quoted verbatim from Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.. - Study
- RCT
- Participants
- 52
- Duration
- 10 days
- Dose
- 100 mg three times a day after meals, total 300 mg/day
- Population
- Adults aged 18-65 with 20-60% total body surface area burns admitted to a burn ICU in Isfahan, Iran, all receiving routine burn care and the unit's standard vitamin, selenium, zinc and B-complex supplementation in both arms; secondary outcome.
Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.2024PMID:38431600Permalink
Show the remaining 4
coenzyme Q10 — no detected effect on erythrocyte sedimentation rate
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“The differences in the CRP and ESR levels were not significant between CoQ10 and placebo groups (P = 0.550 and P = 0.306, respectively) (Table 2).”
Quoted verbatim from Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.. - Study
- RCT
- Participants
- 52
- Duration
- 10 days
- Dose
- 100 mg three times a day after meals, total 300 mg/day
- Population
- Adults aged 18-65 with 20-60% total body surface area burns admitted to a burn ICU in Isfahan, Iran, all receiving routine burn care and the unit's standard vitamin, selenium, zinc and B-complex supplementation in both arms; primary outcome.
Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.2024PMID:38431600Permalink
coenzyme Q10 — no detected effect on superoxide dismutase activity
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“As shown in Table 2, the between-group comparison revealed no significant difference between CoQ10 and placebo groups at the end of the study for MDA (P = 0.692), SOD activity (P = 0.633), and TAC (P = 0.865).”
Quoted verbatim from Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.. - Study
- RCT
- Participants
- 52
- Duration
- 10 days
- Dose
- 100 mg three times a day after meals, total 300 mg/day
- Population
- Adults aged 18-65 with 20-60% total body surface area burns admitted to a burn ICU in Isfahan, Iran, all receiving routine burn care and the unit's standard vitamin, selenium, zinc and B-complex supplementation in both arms; primary outcome.
Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.2024PMID:38431600Permalink
coenzyme Q10 — no detected effect on total antioxidant capacity
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull resultreplicated ×2“As shown in Table 2, the between-group comparison revealed no significant difference between CoQ10 and placebo groups at the end of the study for MDA (P = 0.692), SOD activity (P = 0.633), and TAC (P = 0.865).”
Quoted verbatim from Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.. - Study
- RCT
- Participants
- 52
- Duration
- 10 days
- Dose
- 100 mg three times a day after meals, total 300 mg/day
- Population
- Adults aged 18-65 with 20-60% total body surface area burns admitted to a burn ICU in Isfahan, Iran, all receiving routine burn care and the unit's standard vitamin, selenium, zinc and B-complex supplementation in both arms; primary outcome.
Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.2024PMID:38431600Permalink
coenzyme Q10 — no detected effect on intensive care unit length of stay
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“ICU length of stay in the CoQ10 group (18.83 ± 10.72) was shorter than the placebo group (23.60 ± 10.03); however, the difference was not statistically significant (P = 0.122).”
Quoted verbatim from Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.. - Study
- RCT
- Participants
- 52
- Duration
- 10 days
- Dose
- 100 mg three times a day after meals, total 300 mg/day
- Population
- Adults aged 18-65 with 20-60% total body surface area burns admitted to a burn ICU in Isfahan, Iran, all receiving routine burn care and the unit's standard vitamin, selenium, zinc and B-complex supplementation in both arms; secondary outcome.
Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.2024PMID:38431600Permalink