Papers/PMID:42594341
Effects of Zinc Supplementation on Glycemic Control, Insulin Resistance, Inflammation and Oxidative Stress in Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Endocrinology, diabetes & metabolism2026The record
9 findings · 1 compound · 9 endpoints · 1 null
What it reported
How to read these marksWhat moved
8 findings
Zn(2+) — decreases C-reactive protein concentration
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Five studies showed a significant reduction in CRP/hs‐CRP following zinc supplementation (SMD = −0.91; 95% CI −1.43 to −0.38; p = 0.0007), with considerable heterogeneity (I 2 = 76%).”
Quoted verbatim from Effects of Zinc Supplementation on Glycemic Control, Insulin Resistance, Inflammation and Oxidative Stress in Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.. - Study
- meta-analysis
- Population
- Adults and children with type 1 or type 2 diabetes, gestational diabetes or prediabetes in 18 pooled RCTs of zinc supplementation against placebo or standard care
Effect -0.91 standardised mean difference, 95% CI -1.43 to -0.38
Effects of Zinc Supplementation on Glycemic Control, Insulin Resistance, Inflammation and Oxidative Stress in Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.2026PMID:42594341Permalink
Zn(2+) — decreases malondialdehyde (circulating)
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Four studies showed significantly lower MDA with zinc supplementation (SMD = −0.76; 95% CI −1.34 to −0.18; p = 0.010), with substantial heterogeneity (I 2 = 77%).”
Quoted verbatim from Effects of Zinc Supplementation on Glycemic Control, Insulin Resistance, Inflammation and Oxidative Stress in Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.. - Study
- meta-analysis
- Population
- Adults and children with type 1 or type 2 diabetes, gestational diabetes or prediabetes in 18 pooled RCTs of zinc supplementation against placebo or standard care
Effect -0.76 standardised mean difference, 95% CI -1.34 to -0.18
Effects of Zinc Supplementation on Glycemic Control, Insulin Resistance, Inflammation and Oxidative Stress in Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.2026PMID:42594341Permalink
Zn(2+) — increases total antioxidant capacity
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Four studies showed significantly higher TAC with zinc supplementation (SMD = 1.79; 95% CI 0.68 to 2.91; p = 0.002), with substantial heterogeneity (I 2 = 92%).”
Quoted verbatim from Effects of Zinc Supplementation on Glycemic Control, Insulin Resistance, Inflammation and Oxidative Stress in Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.. - Study
- meta-analysis
- Population
- Adults and children with type 1 or type 2 diabetes, gestational diabetes or prediabetes in 18 pooled RCTs of zinc supplementation against placebo or standard care
Effect 1.79 standardised mean difference, 95% CI 0.68 to 2.91
Effects of Zinc Supplementation on Glycemic Control, Insulin Resistance, Inflammation and Oxidative Stress in Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.2026PMID:42594341Permalink
Zn(2+) — decreases total cholesterol (TC)
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Six studies demonstrated significantly lower total cholesterol with zinc supplementation (MD = −5.70; 95% CI −7.50 to −3.89; p < 0.00001), with negligible heterogeneity (I 2 = 0%).”
Quoted verbatim from Effects of Zinc Supplementation on Glycemic Control, Insulin Resistance, Inflammation and Oxidative Stress in Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.. - Study
- meta-analysis
- Population
- Adults and children with type 1 or type 2 diabetes, gestational diabetes or prediabetes in 18 pooled RCTs of zinc supplementation against placebo or standard care
Effect -5.7 mean difference, 95% CI -7.5 to -3.89
Effects of Zinc Supplementation on Glycemic Control, Insulin Resistance, Inflammation and Oxidative Stress in Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.2026PMID:42594341Permalink
- ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding
“Zinc supplementation significantly reduced HOMA‐IR (MD = −1.10; 95% CI −2.05 to −0.15; p = 0.02), with considerable heterogeneity (I 2 = 79%).”
Quoted verbatim from Effects of Zinc Supplementation on Glycemic Control, Insulin Resistance, Inflammation and Oxidative Stress in Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.. - Study
- meta-analysis
- Population
- Adults and children with type 1 or type 2 diabetes, gestational diabetes or prediabetes in 18 pooled RCTs of zinc supplementation against placebo or standard care
Effect -1.1 mean difference, 95% CI -2.05 to -0.15
Effects of Zinc Supplementation on Glycemic Control, Insulin Resistance, Inflammation and Oxidative Stress in Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.2026PMID:42594341Permalink
Zn(2+) — increases body mass index
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Four studies reported significantly higher BMI with zinc supplementation (MD = 0.85; 95% CI 0.57 to 1.14; p < 0.00001; I 2 = 0%).”
Quoted verbatim from Effects of Zinc Supplementation on Glycemic Control, Insulin Resistance, Inflammation and Oxidative Stress in Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.. - Study
- meta-analysis
- Population
- Adults and children with type 1 or type 2 diabetes, gestational diabetes or prediabetes in 18 pooled RCTs of zinc supplementation against placebo or standard care
Effect 0.85 mean difference, 95% CI 0.57 to 1.14
Effects of Zinc Supplementation on Glycemic Control, Insulin Resistance, Inflammation and Oxidative Stress in Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.2026PMID:42594341Permalink
Show the remaining 2
- ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding
“Two studies showed significantly higher body weight with zinc supplementation (MD = 2.38; 95% CI 1.40 to 3.35; p < 0.00001; I 2 = 0%).”
Quoted verbatim from Effects of Zinc Supplementation on Glycemic Control, Insulin Resistance, Inflammation and Oxidative Stress in Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.. - Study
- meta-analysis
- Population
- Adults and children with type 1 or type 2 diabetes, gestational diabetes or prediabetes in 18 pooled RCTs of zinc supplementation against placebo or standard care
Effect 2.38 mean difference, 95% CI 1.4 to 3.35
Effects of Zinc Supplementation on Glycemic Control, Insulin Resistance, Inflammation and Oxidative Stress in Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.2026PMID:42594341Permalink
Zn(2+) — increases LDL cholesterol
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.Finding“Seven studies demonstrated a significant increase in LDL cholesterol with zinc supplementation (MD = 3.46; 95% CI 1.48 to 5.43; p = 0.0006), with very low heterogeneity (I 2 = 3%).”
Quoted verbatim from Effects of Zinc Supplementation on Glycemic Control, Insulin Resistance, Inflammation and Oxidative Stress in Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.. - Study
- meta-analysis
- Population
- Adults and children with type 1 or type 2 diabetes, gestational diabetes or prediabetes in 18 pooled RCTs of zinc supplementation against placebo or standard care
Effect 3.46 mean difference, 95% CI 1.48 to 5.43
Effects of Zinc Supplementation on Glycemic Control, Insulin Resistance, Inflammation and Oxidative Stress in Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.2026PMID:42594341Permalink
What did not
1 finding
Zn(2+) — no detected effect on fasting blood glucose
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“Zinc supplementation did not significantly affect FBG (MD = −0.61; 95% CI −1.83 to 0.60; p = 0.32), with considerable heterogeneity (I 2 = 95%).”
Quoted verbatim from Effects of Zinc Supplementation on Glycemic Control, Insulin Resistance, Inflammation and Oxidative Stress in Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.. - Study
- meta-analysis
- Population
- Adults and children with type 1 or type 2 diabetes, gestational diabetes or prediabetes in 18 pooled RCTs of zinc supplementation against placebo or standard care
Effect -0.61 mean difference, 95% CI -1.83 to 0.6
Effects of Zinc Supplementation on Glycemic Control, Insulin Resistance, Inflammation and Oxidative Stress in Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.2026PMID:42594341Permalink