Papers/PMID:41804854
Alpha-lipoic acid as a preventive measure in radiation-induced oral mucositis in head and neck cancer patients: A randomized controlled study.
British journal of clinical pharmacology2026The record
2 findings · 1 compound · 2 endpoints · 1 null
What it reported
How to read these marksWhat moved
1 finding
lipoic acid — increases total antioxidant capacity
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“ALA significantly improved TAC levels but had no effect on CRP.”
Quoted verbatim from Alpha-lipoic acid as a preventive measure in radiation-induced oral mucositis in head and neck cancer patients: A randomized controlled study.. - Study
- RCT
- Dose
- 600 mg twice daily
- Population
- Head and neck cancer patients receiving definitive radiotherapy, randomised to oral ALA or placebo tablets throughout the radiotherapy period
Alpha-lipoic acid as a preventive measure in radiation-induced oral mucositis in head and neck cancer patients: A randomized controlled study.2026PMID:41804854Permalink
What did not
1 finding
lipoic acid — no detected effect on C-reactive protein concentration
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“ALA significantly improved TAC levels but had no effect on CRP.”
Quoted verbatim from Alpha-lipoic acid as a preventive measure in radiation-induced oral mucositis in head and neck cancer patients: A randomized controlled study.. - Study
- RCT
- Dose
- 600 mg twice daily
- Population
- Head and neck cancer patients receiving definitive radiotherapy, randomised to oral ALA or placebo tablets throughout the radiotherapy period
Alpha-lipoic acid as a preventive measure in radiation-induced oral mucositis in head and neck cancer patients: A randomized controlled study.2026PMID:41804854Permalink