Papers/PMID:32386521
The effect of glutamine on Dehydroepiandrosterone-induced polycystic ovary syndrome rats.
Journal of ovarian research2020The record
4 findings · 1 compound · 4 endpoints
What it reported
How to read these marksWhat moved
4 findings
L-glutamine — decreases C-reactive protein concentration
SpeculativeGrade F, Speculative. Mechanistic inference, no evidence found, or evidence weakened below D.Findingreplicated ×1“All the detected inflammation factors [C-reactive protein, interleukin (IL)-6, IL-18, tumor necrosis factor] showed significantly higher in all the PCOS groups compared to the control group (P < 0.01), and were significantly decreased with the supplementation of 0.5 g/kg glutamine (P < 0.01).”
Quoted verbatim from The effect of glutamine on Dehydroepiandrosterone-induced polycystic ovary syndrome rats.. - Study
- animal · not in humans
- Dose
- 0.5 g/kg, intraperitoneal, twice on the morning after the last DHEA injection
- Population
- Female Sprague-Dawley rats, DHEA-induced PCOS model, 0.5 g/kg glutamine dose
The effect of glutamine on Dehydroepiandrosterone-induced polycystic ovary syndrome rats.2020PMID:32386521Permalink
L-glutamine — decreases interleukin-6 concentration
SpeculativeGrade F, Speculative. Mechanistic inference, no evidence found, or evidence weakened below D.Findingreplicated ×2“All the detected inflammation factors [C-reactive protein, interleukin (IL)-6, IL-18, tumor necrosis factor] showed significantly higher in all the PCOS groups compared to the control group (P < 0.01), and were significantly decreased with the supplementation of 0.5 g/kg glutamine (P < 0.01).”
Quoted verbatim from The effect of glutamine on Dehydroepiandrosterone-induced polycystic ovary syndrome rats.. - Study
- animal · not in humans
- Dose
- 0.5 g/kg, intraperitoneal, twice on the morning after the last DHEA injection
- Population
- Female Sprague-Dawley rats, DHEA-induced PCOS model, 0.5 g/kg glutamine dose
The effect of glutamine on Dehydroepiandrosterone-induced polycystic ovary syndrome rats.2020PMID:32386521Permalink
L-glutamine — increases superoxide dismutase activity
SpeculativeGrade F, Speculative. Mechanistic inference, no evidence found, or evidence weakened below D.Finding“Concentrations of superoxide dismutase were significantly lower in all the PCOS groups (P < 0.01) compared to the control group, and increased significantly with the supplementation of 0.5 g/kg glutamine (P < 0.01).”
Quoted verbatim from The effect of glutamine on Dehydroepiandrosterone-induced polycystic ovary syndrome rats.. - Study
- animal · not in humans
- Dose
- 0.5 g/kg, intraperitoneal, twice on the morning after the last DHEA injection
- Population
- Female Sprague-Dawley rats, DHEA-induced PCOS model, 0.5 g/kg glutamine dose
The effect of glutamine on Dehydroepiandrosterone-induced polycystic ovary syndrome rats.2020PMID:32386521Permalink
L-glutamine — decreases malondialdehyde (circulating)
SpeculativeGrade F, Speculative. Mechanistic inference, no evidence found, or evidence weakened below D.Finding“Serum concentrations of malondialdehyde, nitric oxide synthase and nitric oxide were significantly higher in PCOS group (P < 0.01) compared with the control group, and significantly decreased to the comparative levels of control group with supplementation of 0.5 g/kg glutamine (P < 0.01).”
Quoted verbatim from The effect of glutamine on Dehydroepiandrosterone-induced polycystic ovary syndrome rats.. - Study
- animal · not in humans
- Dose
- 0.5 g/kg, intraperitoneal, twice on the morning after the last DHEA injection
- Population
- Female Sprague-Dawley rats, DHEA-induced PCOS model, 0.5 g/kg glutamine dose
The effect of glutamine on Dehydroepiandrosterone-induced polycystic ovary syndrome rats.2020PMID:32386521Permalink