(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA

Three steps

• S-octanoyl-4'-phosphopantetheineReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  3. octanoyl-CoA + H2O = S-octanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by BAAT, ACOT6, CROT, NUDT19 and 2 morecytosol, mitochondrial matrix

• decanoyl-4'-phosphopantetheineReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. medium-chain acyl-CoA ligase (decanoic acid)
  3. decanoyl-CoA + H2O = decanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by BAAT, ACOT6, ACSM4, ACSM1 and 5 morecytosol

• S-dodecanoyl-4'-phosphopantetheineReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (lauric acid)
  3. dodecanoyl-CoA + H2O = S-dodecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 8 morecytosol

• tetradecanoyl-4'-phosphopantetheineReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. tetradecanoyl-CoA + H2O = tetradecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 8 morecytosol

• tauroursodeoxycholateReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. taurine to tauroursodeoxycholate conversion

  Catalysed by BAAT, ACOT6cytosolOne of 2 routes

• glycoursodeoxycholateReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. glycine to glycoursodeoxycholate conversion

  Catalysed by BAAT, ACOT6, GLYAT, GLYATL2 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• leukotriene F4Reach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. leukotriene F4 hydrolysis

  Catalysed by BAAT, ACOT6, ZDHHC11B, NAA10 and 30 morecytosol

• 14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoateReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA hydrolase
  3. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 = 14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 3 moreperoxisome, cytosol

• 19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoateReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA hydrolase
  3. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 19,20-epoxy-(7Z,10Z,13Z,16Z)-docosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 4 moreperoxisome, cytosol

• 16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoateReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA hydrolase
  3. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 16,17-epoxy-(7Z,10Z,13Z,19Z)-docosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 4 moreperoxisome, cytosol

• 13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoateReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA hydrolase
  3. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 13,14-epoxy-(7Z,10Z,16Z,19Z)-docosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 4 moreperoxisome, cytosol

• 10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoateReach from here →
  1. Beta Oxidation of Long Chain Fatty Acid
  2. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA hydrolase
  3. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 10,11-epoxy-(7Z,13Z,16Z,19Z)-docosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 4 moreperoxisome, cytosol

• 2,4-dinitrophenyl-S-glutathioneReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. transport of leukotriene E4 (cytosol to extracellular)

  Catalysed by BAAT, ACOT6, ZDHHC11B, NAA10 and 31 morecytosol, extracellular spaceOne of 2 routes

• N-(9Z-octadecenoyl)glycineReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)

  Catalysed by BAAT, ACOT6, GLYAT, GLYATL2 and 2 morecytosol, mitochondrial matrix

• N-octadecanoylglycineReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. octadecanoyl-CoA + glycine = N-octadecanoylglycine + CoA + H(+)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosolOne of 2 routes

• N-(9Z-hexadecenoyl)-glycineReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (palmitolate)
  3. (9Z)-hexadecenoyl-CoA + glycine = N-(9Z-hexadecenoyl)-glycine + CoA + H(+)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 7 morecytosolOne of 2 routes

• 2-hydroxyoctanoyl-CoAReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  3. octanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyoctanoyl-CoA + succinate + CO2

  Catalysed by BAAT, ACOT6, CROT, PHYHcytosol, mitochondrial matrix

• 2-hydroxydecanoyl-CoAReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. medium-chain acyl-CoA ligase (decanoic acid)
  3. decanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxydecanoyl-CoA + succinate + CO2

  Catalysed by BAAT, ACOT6, ACSM4, ACSM1 and 5 morecytosol

• 2-hydroxyeicosanoyl-CoAReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)
  3. eicosanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyeicosanoyl-CoA + succinate + CO2

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 7 morecytosol

• 2-hydroxydodecanoyl-CoAReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (lauric acid)
  3. dodecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxydodecanoyl-CoA + succinate + CO2

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 7 morecytosol

• 2-hydroxytetradecanoyl-CoAReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. tetradecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxytetradecanoyl-CoA + succinate + CO2

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 7 morecytosol

• 11-cis-retinyl tetradecanoateReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. 11-cis-retinol + tetradecanoyl-CoA = 11-cis-retinyl tetradecanoate + CoA

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 7 morecytosolOne of 2 routes

• 9-cis-retinyl tetradecanoateReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. 9-cis-retinol + tetradecanoyl-CoA = 9-cis-retinyl tetradecanoate + CoA

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 7 morecytosol

• 13-cis-retinyl tetradecanoateReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. 13-cis-retinol + tetradecanoyl-CoA = 13-cis-retinyl tetradecanoate + CoA

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 7 morecytosol

• all-trans-retinyl tetradecanoateReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. all-trans-retinol + tetradecanoyl-CoA = all-trans-retinyl tetradecanoate + CoA

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 7 morecytosol

• tetradecyl tetradecanoateReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. tetradecan-1-ol + tetradecanoyl-CoA = tetradecyl tetradecanoate + CoA

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 7 morecytosol

• 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphateReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (DHA)
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 7 morecytosol

• N-hexadecanoylglycineReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)

  Catalysed by BAAT, ACOT6, GLYAT, GLYATL2 and 2 morecytosol, mitochondrial matrix

• N-dodecanoylglycineReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (lauric acid)
  3. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 7 morecytosolOne of 2 routes

• N-decanoylglycineReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. medium-chain acyl-CoA ligase (decanoic acid)
  3. decanoyl-CoA + glycine = N-decanoylglycine + CoA + H(+)

  Catalysed by BAAT, ACOT6, ACSM4, ACSM1 and 5 morecytosolOne of 2 routes

• N-octanoylglycineReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  3. octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)

  Catalysed by BAAT, ACOT6, CROT, GLYATL2cytosol, mitochondrial matrixOne of 2 routes

• N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

  Catalysed by BAAT, ACOT6, GLYAT, GLYATL2 and 2 morecytosol, mitochondrial matrix

• L-cystine-bis-glycineReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine

  Catalysed by BAAT, ACOT6, GLYAT, GLYATL2 and 3 morecytosol, mitochondrial matrix

• a 2-acyl-6-[alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA
  3. a 2-acyl-6-[alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 2-acyl-6-[alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycerol

  Catalysed by LPCAT4, LPCAT3, MBOAT1, MBOAT2 and 1 morecytosol

• a 2-acyl-6-[2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA
  3. a 2-acyl-6-(alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl)-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 2-acyl-6-[2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycerol

  Catalysed by LPCAT4, LPCAT3, MBOAT1, MBOAT2 and 1 morecytosol

• a 2-acyl-6-[6-phosphoethanolamine-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA
  3. a 2-acyl-6-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 2-acyl-6-[6-phosphoethanolamine-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycerol

  Catalysed by LPCAT4, LPCAT3, MBOAT1, MBOAT2 and 1 morecytosol

• a 2-acyl-6-[6-phosphoethanolamine-alpha-D-mannosyl-(1->2)-6-phosphoethanolamine-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA
  3. a 2-acyl-6-[6-phosphoethanolamine-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a 2-acyl-6-[6-phosphoethanolamine-alpha-D-mannosyl-(1->2)-6-phosphoethanolamine-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a 1,2-diacyl-sn-glycerol

  Catalysed by LPCAT4, LPCAT3, MBOAT1, MBOAT2 and 1 morecytosol

• an N-octadecanoyl-sphingoid baseReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. a sphingoid base + octadecanoyl-CoA = an N-octadecanoyl-sphingoid base + CoA + H(+)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 6 morecytosol

• glycyldehydrophenylalanineReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

  Catalysed by BAAT, ACOT6, GLYAT, GLYATL2 and 2 morecytosol, mitochondrial matrix

• an N-(fatty acyl)-glycineReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by BAAT, ACOT6, GLYAT, GLYATL2 and 1 morecytosol, mitochondrial matrix

• 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. 1-(10Z-heptadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoyl-CoA = 1-(10Z-heptadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 7 morecytosol

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by BAAT, ACOT6, SLC27A2, ACSL4 and 7 morecytosolOne of 2 routes

• cholesteryl (7Z)-octadecenoateReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)
  3. (7Z)-octadecenoyl-CoA + cholesterol = cholesteryl (7Z)-octadecenoate + CoA

  Catalysed by BAAT, ACOT6, CPT1A, CPT1C and 2 morecytosol

• acetylcholineReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by BAAT, ACOT6, CHATcytosol, nucleusOne of 3 routes

• pyruvateReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by BAAT, ACOT6, AGXT2cytosol, mitochondrial matrixOne of 20 routes

• CHEBI:15467Reach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. Acetoacetate:CoA ligase (AMP-forming)
  3. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)

  Catalysed by BAAT, ACOT6, AACS, HMGCS1cytosolOne of 3 routes

• CHEBI:15570Reach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by BAAT, ACOT6, GLYAT, GLYATL2 and 3 morecytosol, mitochondrial matrix, extracellular spaceOne of 3 routes

• (S)-malateReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. ATP citrate lyase (citrate)
  3. transport of malate and OAA (cytosol to mitochondria)

  Catalysed by BAAT, ACOT6, ACLYcytosol, mitochondrial matrixOne of 5 routes

• L-leucineReach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and leucine (cytosol to extracellular)

  Catalysed by BAAT, ACOT6, GLYAT, GLYATL2 and 2 morecytosol, mitochondrial matrix, extracellular spaceOne of 21 routes

• CHEBI:15611Reach from here →
  1. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA hydrolase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by BAAT, ACOT6, GLYAT, GLYATL2 and 2 morecytosol, mitochondrial matrix