(6S)-5,6,7,8-tetrahydrofolate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

446 compounds within 3 steps: 4 in 1, 80 in 2, 362 in 3

Three steps

(11Z)-eicosenoyl-CoAReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)
Catalysed by SHMT1, SHMT2, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 7 routes
(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)
Catalysed by SHMT1, SHMT2, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 5 routes
(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)
Catalysed by SHMT1, SHMT2, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 4 routes
(15Z)-tetracosenoyl-CoAReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (nervonic acid)
Catalysed by SHMT1, SHMT2, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 6 routes
(17Z)-hexacosenoyl-CoAReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (ximenic acid)
Catalysed by SHMT1, SHMT2, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 4 routes
(8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)
Catalysed by SHMT1, SHMT2, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 5 routes
(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)
Catalysed by SHMT1, SHMT2, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 5 routes
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (DHA)
Catalysed by SHMT1, SHMT2, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 7 routes
heptadecanoyl-CoAReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (margaric acid)
Catalysed by SHMT1, SHMT2, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 6 routes
(9Z)-heptadecenoyl-CoAReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)
Catalysed by SHMT1, SHMT2, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 5 routes
(11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)
Catalysed by SHMT1, SHMT2, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 5 routes
nonadecanoyl-CoAReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (nonadecylic acid)
Catalysed by SHMT1, SHMT2, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 6 routes
(11Z)-octadecenoyl-CoAReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase
3. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix
Catalysed by SHMT1, SHMT2, BAAT, CPT1A and 2 moreperoxisome, cytosolOne of 3 routes
dodecanedioyl-CoAReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase
3. Activation of dodecanedioic acid
Catalysed by SHMT1, SHMT2, BAATperoxisome, cytosolOne of 4 routes
decanedioyl-CoAReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase
3. Production of Sebacoylcarnitine
Catalysed by SHMT1, SHMT2, BAAT, CPT1A and 2 moreperoxisome, cytosolOne of 4 routes
octanedioyl-CoAReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase
3. Production of Suberylcarnitine
Catalysed by SHMT1, SHMT2, BAAT, CPT1A and 2 moreperoxisome, cytosolOne of 4 routes
hexanedioyl-CoAReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase
3. Activation of adipic acid for Formation of Adipoyl Carnitine
Catalysed by SHMT1, SHMT2, BAATperoxisome, cytosolOne of 4 routes
(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)
Catalysed by SHMT1, SHMT2, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 7 routes
(11Z,14Z)-eicosadienoyl-CoAReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)
Catalysed by SHMT1, SHMT2, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 5 routes
(R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase
3. Production of 3-Hydroxyoctadecenoylcarnitinec
Catalysed by SHMT1, SHMT2, BAAT, CPT1A and 2 moreperoxisome, cytosol
(13Z)-eicosenoyl-CoAReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)
Catalysed by SHMT1, SHMT2, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 5 routes
20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2
Catalysed by SHMT1, SHMT2, GSS, SLCO2A1cytosol, extracellular spaceOne of 2 routes
4,8-dimethylnonanoyl-CoAReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase
3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal
Catalysed by SHMT1, SHMT2, BAAT, CRAT and 1 moreperoxisomeOne of 3 routes
tetradecanedioyl-CoAReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase
3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal
Catalysed by SHMT1, SHMT2, BAAT, ACAA1 and 3 moreperoxisome
hexadecanedioyl-CoAReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase
3. Production of Hexadecanedioylcarnitine
Catalysed by SHMT1, SHMT2, BAAT, CPT1A and 2 moreperoxisome, cytosolOne of 2 routes
pristanoyl-CoAReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase
3. fatty-acid-CoA ligase
Catalysed by SHMT1, SHMT2, BAAT, SLC27A2peroxisome, cytosolOne of 2 routes
undecanoyl-CoAReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase
3. medium-chain acyl-CoA ligase (undecylic acid)
Catalysed by SHMT1, SHMT2, BAAT, ACSM4 and 5 moreperoxisome, cytosolOne of 3 routes
a fatty acyl-CoAReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)
3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)
Catalysed by SHMT1, SHMT2, GLYATL2
(9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. (9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O
Catalysed by SHMT1, SHMT2, GSS, GPX1 and 1 more
ursodeoxycholateReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
3. transport of GSH and ursodeoxycholate (cytosol to extracellular)
Catalysed by SHMT1, SHMT2, GSS, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 2 routes
prostaglandin G2Reach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
3. transport of GSH and prostaglandin G2 (cytosol to extracellular)
Catalysed by SHMT1, SHMT2, GSS, SLCO2A1cytosol, extracellular spaceOne of 2 routes
thio-Mo-molybdopterinReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. transport of cysteine and glycine (cytosol to extracellular)
3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
Catalysed by SHMT1, SHMT2, SLC3A2, SLC7A5 and 2 moreextracellular space, cytosol
(12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O
Catalysed by SHMT1, SHMT2, GSS, GPX1 and 2 more
(5Z)-tetradecenoyl-CoAReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (physeteric acid)
Catalysed by SHMT1, SHMT2, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 8 routes
(3E)-decenoyl-CoAReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase
3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial
Catalysed by SHMT1, SHMT2, BAAT, ACADM and 3 moreperoxisome, mitochondrial matrix
(2R,6)-dimethylheptanoyl-CoAReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase
3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)
Catalysed by SHMT1, SHMT2, BAAT, HADHA and 2 moreperoxisome, mitochondrial matrix
an N(2)-acyl-L-glutamineReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. transport of glutamine and glycine (cytosol to extracellular)
3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
Catalysed by SHMT1, SHMT2, SLC7A5, GLYATL1B and 1 moreextracellular space, cytosol
(7Z)-hexadecenoyl-CoAReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)
Catalysed by SHMT1, SHMT2, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 8 routes
3-methylmalateReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
3. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)
Catalysed by SHMT1, SHMT2, AADAT, CLYBL
tricosanoyl-CoAReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. bile acid-CoA: amino acid N-acyltransferase
3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)
Catalysed by SHMT1, SHMT2, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 4 routes
(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
Catalysed by SHMT1, SHMT2, GSS, PTGES and 5 more
(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O
Catalysed by SHMT1, SHMT2, GSS, GPX1 and 1 more
thromboxane B2Reach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
3. transport of GSH and thromboxane B2 (cytosol to extracellular)
Catalysed by SHMT1, SHMT2, GSS, SLCO1B1cytosol, extracellular spaceOne of 2 routes
an S-substituted glutathioneReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)
Catalysed by SHMT1, SHMT2, GSS, GSTT4 and 22 moreOne of 2 routes
(13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
3. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O
Catalysed by SHMT1, SHMT2, GSS, GPX1 and 3 more
taurochenodeoxycholateReach from here →
1. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
3. solute carrier organic anion transporter (GSH)
Catalysed by SHMT1, SHMT2, GSS, SLCO1A2 and 2 morecytosol, extracellular spaceOne of 3 routes