D-glucose

Three steps

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. dATP:D-glucose 6-phosphotransferase
  2. dATP:pyruvate 2-O-phosphotransferase
  3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by HK1, HK2, HK3, HKDC1 and 3 morecytosol

• 2-methyl-3-oxopropanoateReach from here →
  1. dATP:D-glucose 6-phosphotransferase
  2. dATP:pyruvate 2-O-phosphotransferase
  3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

  Catalysed by HK1, HK2, HK3, HKDC1 and 3 morecytosol

• L-methionineReach from here →
  1. dATP:D-glucose 6-phosphotransferase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by HK1, HK2, HK3, HKDC1 and 5 morecytosol, mitochondrial matrixOne of 3 routes

• L-tryptophanReach from here →
  1. dATP:D-glucose 6-phosphotransferase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by HK1, HK2, HK3, HKDC1 and 5 morecytosol, mitochondrial matrixOne of 2 routes

• L-alanineReach from here →
  1. dATP:D-glucose 6-phosphotransferase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by HK1, HK2, HK3, HKDC1 and 5 morecytosol, mitochondrial matrixOne of 20 routes

• L-asparagineReach from here →
  1. dATP:D-glucose 6-phosphotransferase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by HK1, HK2, HK3, HKDC1 and 5 morecytosol, mitochondrial matrixOne of 2 routes

• IMPReach from here →
  1. dATP:D-glucose 6-phosphotransferase
  2. dADP to dATP conversion
  3. dGMP + inosine = 2'-deoxyguanosine + IMP

  Catalysed by HK1, HK2, HK3, HKDC1 and 1 morecytosol, mitochondrial matrix

• L-phenylalanineReach from here →
  1. dATP:D-glucose 6-phosphotransferase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by HK1, HK2, HK3, HKDC1 and 5 morecytosol, mitochondrial matrixOne of 2 routes

• alpha-D-galactose 1-phosphateReach from here →
  1. UDP-alpha-D-galactose:D-glucose 4-beta-D-galactosyltransferase
  2. Lactose galactohydrolase
  3. galactokinase (galactose)

  Catalysed by B4GALT2, LALBA, B4GALT1, LCT and 5 moreGolgi apparatus, extracellular space, cytosolOne of 2 routes

• alpha-D-mannose 1-phosphateReach from here →
  1. D-glucose + ADP = D-glucose 6-phosphate + AMP + H(+)
  2. D-glucose 6-phosphate = D-mannose 6-phosphate
  3. alpha-D-mannose 1-phosphate = D-mannose 6-phosphate

  Catalysed by ADPGK, GPI, PMM2, PMM1

• dCDPReach from here →
  1. dATP:D-glucose 6-phosphotransferase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. 2'-deoxycytidine diphosphate:oxidized-thioredoxin 2'-oxidoreductase

  Catalysed by HK1, HK2, HK3, HKDC1 and 5 morecytosol, mitochondrial matrixOne of 18 routes

• (3S)-citramalyl-CoAReach from here →
  1. dATP:D-glucose 6-phosphotransferase
  2. dATP:pyruvate 2-O-phosphotransferase
  3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

  Catalysed by HK1, HK2, HK3, HKDC1 and 3 morecytosol

• 5-amino-2-oxopentanoateReach from here →
  1. dATP:D-glucose 6-phosphotransferase
  2. dATP:pyruvate 2-O-phosphotransferase
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by HK1, HK2, HK3, HKDC1 and 3 morecytosol

• dCTPReach from here →
  1. dATP:D-glucose 6-phosphotransferase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase

  Catalysed by HK1, HK2, HK3, HKDC1 and 5 morecytosol, mitochondrial matrixOne of 2 routes

• D-fructose 6-phosphateReach from here →
  1. D-glucose + ADP = D-glucose 6-phosphate + AMP + H(+)
  2. D-glucose 6-phosphate = D-mannose 6-phosphate
  3. D-mannose 6-phosphate = D-fructose 6-phosphate

  Catalysed by ADPGK, GPI, MPI

• dUTPReach from here →
  1. dATP:D-glucose 6-phosphotransferase
  2. 2-Deoxyuridine 5-Diphosphate:Oxidized-Thioredoxin 2-Oxidoreductase
  3. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase

  Catalysed by HK1, HK2, HK3, HKDC1 and 5 morecytosol, mitochondrial matrixOne of 3 routes

• a ribonucleoside 5'-triphosphateReach from here →
  1. dATP:D-glucose 6-phosphotransferase
  2. cytidine/uridine monophosphate kinase (dADP)
  3. 2'-deoxycytidine + a ribonucleoside 5'-triphosphate = dCMP + a ribonucleoside 5'-diphosphate + H(+)

  Catalysed by HK1, HK2, HK3, HKDC1 and 2 morecytosol

• (4R)-4-hydroxy-2-oxoglutarateReach from here →
  1. dATP:D-glucose 6-phosphotransferase
  2. dATP:pyruvate 2-O-phosphotransferase
  3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by HK1, HK2, HK3, HKDC1 and 3 morecytosol

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. dATP:D-glucose 6-phosphotransferase
  2. dATP:pyruvate 2-O-phosphotransferase
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by HK1, HK2, HK3, HKDC1 and 3 morecytosol

• NAADP(+)Reach from here →
  1. ATP:D-glucose 6-phosphotransferase
  2. D-glucose-6-phosphate:NADP+ 1-oxidoreductase
  3. NAADP(+) + D-glucose 6-phosphate = NAADPH + 6-phospho-D-glucono-1,5-lactone + H(+)

  Catalysed by HK1, GCK, HK2, HK3 and 2 morecytosol, endoplasmic reticulumOne of 4 routes

• thiamine(1+) diphosphateReach from here →
  1. dATP:D-glucose 6-phosphotransferase
  2. ATP:dADP phosphotransferase
  3. Antiport of thiamine-diphosphate and dATP

  Catalysed by HK1, HK2, HK3, HKDC1 and 6 morecytosol, mitochondrial matrixOne of 2 routes

• 2-(1-hydroxyethyl)thiamine diphosphateReach from here →
  1. dATP:D-glucose 6-phosphotransferase
  2. dATP:pyruvate 2-O-phosphotransferase
  3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

  Catalysed by HK1, HK2, HK3, HKDC1 and 5 morecytosol, mitochondrial matrix