sphingosine 1-phosphate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

264 compounds within 3 steps: 4 in 1, 27 in 2, 233 in 3

Three steps

(9Z)-heptadecenoyl-CoAReach from here →
1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
2. Fas180
3. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)
Catalysed by SGPL1, SLC27A2, ACSL4, ACSL3 and 5 moreendoplasmic reticulum, cytosolOne of 5 routes
(11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
2. Fas180
3. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)
Catalysed by SGPL1, SLC27A2, ACSL4, ACSL3 and 5 moreendoplasmic reticulum, cytosolOne of 5 routes
1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
1. sphingosine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming)
2. CTP:ethanolamine-phosphate cytidylyltransferase
3. CDP-ethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)
Catalysed by SGPL1, PCYT2, CEPT1cytosol
1-octadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. 3-sn-phosphatidate phosphohydrolase
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine = 1-octadecanoyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 4 morecytosol
nonadecanoyl-CoAReach from here →
1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
2. Fas180
3. long-chain-fatty-acid-CoA ligase (nonadecylic acid)
Catalysed by SGPL1, SLC27A2, ACSL4, ACSL3 and 5 moreendoplasmic reticulum, cytosolOne of 6 routes
(11Z)-octadecenoyl-CoAReach from here →
1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
2. Fas180
3. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix
Catalysed by SGPL1, CPT1A, CPT1C, CPT1Bendoplasmic reticulum, cytosolOne of 3 routes
1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerolReach from here →
1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
2. Fas180
3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + octadecanoate + H(+)
Catalysed by SGPL1, ABHD11endoplasmic reticulum, cytosol
1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enineReach from here →
1. 3-sn-phosphatidate phosphohydrolase
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 4 morecytosolOne of 8 routes
2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
1. 3-sn-phosphatidate phosphohydrolase
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 4 morecytosolOne of 2 routes
1-octadecanoyl-N-(acetyl)-sphing-4-enineReach from here →
1. 3-sn-phosphatidate phosphohydrolase
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 4 morecytosolOne of 5 routes
2-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. 3-sn-phosphatidate phosphohydrolase
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 2-octadecanoyl-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 4 morecytosol
1-hexadecanoyl-N-(acetyl)-sphing-4-enineReach from here →
1. 3-sn-phosphatidate phosphohydrolase
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 4 morecytosolOne of 9 routes
2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. 3-sn-phosphatidate phosphohydrolase
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 4 morecytosol
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholineReach from here →
1. 3-sn-phosphatidate phosphohydrolase
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 4 morecytosolOne of 2 routes
1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enineReach from here →
1. 3-sn-phosphatidate phosphohydrolase
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 4 morecytosolOne of 3 routes
2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineReach from here →
1. 3-sn-phosphatidate phosphohydrolase
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 4 morecytosol
2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholineReach from here →
1. 3-sn-phosphatidate phosphohydrolase
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 4 morecytosol
1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enineReach from here →
1. 3-sn-phosphatidate phosphohydrolase
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 4 morecytosolOne of 3 routes
1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enineReach from here →
1. 3-sn-phosphatidate phosphohydrolase
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 4 morecytosol
2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
1. 3-sn-phosphatidate phosphohydrolase
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 4 morecytosol
2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. 3-sn-phosphatidate phosphohydrolase
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 4 morecytosol
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. 3-sn-phosphatidate phosphohydrolase
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 4 morecytosol
a 1-O-alkyl-sn-glycero-3-phosphoethanolamineReach from here →
1. sphingosine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming)
2. Phosphoethanolamine phosphohydrolase
3. a 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)
Catalysed by SGPL1, PHOSPHO1, ENPP2cytosol
hexadecanedioateReach from here →
1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
2. Fatty Acid Omega Oxidation (C16->W-Ohc16), Endoplasmatic Reticulum
3. Fatty Acid Omega Oxidation (W-Ohc16->C16Dc)
Catalysed by SGPL1, CYP4F2, CYP4F3, ADH5 and 1 moreendoplasmic reticulum, cytosol
beta-D-glucosyl-N-dodecanoylsphing-4-enineReach from here →
1. 3-sn-phosphatidate phosphohydrolase
2. N-dodecanoylsphing-4-enine + H2O = dodecanoate + sphing-4-enine
3. beta-D-glucosyl-N-dodecanoylsphing-4-enine + cholesterol = N-dodecanoylsphing-4-enine + cholesteryl 3-beta-D-glucoside
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 7 morecytosol
beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enineReach from here →
1. 3-sn-phosphatidate phosphohydrolase
2. N-(15Z-tetracosenoyl)-sphing-4-enine + H2O = (15Z)-tetracosenoate + sphing-4-enine
3. beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol = N-(15Z-tetracosenoyl)-sphing-4-enine + cholesteryl 3-beta-D-glucoside
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 6 morecytosol
dodecanedioyl-CoAReach from here →
1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
2. Fas180
3. Activation of dodecanedioic acid
Catalysed by SGPL1endoplasmic reticulum, cytosolOne of 4 routes
decanedioyl-CoAReach from here →
1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
2. Fas180
3. Production of Sebacoylcarnitine
Catalysed by SGPL1, CPT1A, CPT1C, CPT1Bendoplasmic reticulum, cytosolOne of 4 routes
octanedioyl-CoAReach from here →
1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
2. Fas180
3. Production of Suberylcarnitine
Catalysed by SGPL1, CPT1A, CPT1C, CPT1Bendoplasmic reticulum, cytosolOne of 4 routes
hexanedioyl-CoAReach from here →
1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
2. Fas180
3. Activation of adipic acid for Formation of Adipoyl Carnitine
Catalysed by SGPL1endoplasmic reticulum, cytosolOne of 4 routes
(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
2. Fas180
3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)
Catalysed by SGPL1, SLC27A2, ACSL4, ACSL3 and 5 moreendoplasmic reticulum, cytosolOne of 7 routes
(11Z,14Z)-eicosadienoyl-CoAReach from here →
1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
2. Fas180
3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)
Catalysed by SGPL1, SLC27A2, ACSL4, ACSL3 and 5 moreendoplasmic reticulum, cytosolOne of 5 routes
2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. 3-sn-phosphatidate phosphohydrolase
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-O-acyl-N-(acetyl)-sphing-4-enine
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 4 morecytosol
(R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
2. Fas180
3. Production of 3-Hydroxyoctadecenoylcarnitinec
Catalysed by SGPL1, CPT1A, CPT1C, CPT1Bendoplasmic reticulum, cytosol
(13Z)-eicosenoyl-CoAReach from here →
1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
2. Fas180
3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)
Catalysed by SGPL1, SLC27A2, ACSL4, ACSL3 and 5 moreendoplasmic reticulum, cytosolOne of 5 routes
4,8-dimethylnonanoyl-CoAReach from here →
1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
2. Fas180
3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal
Catalysed by SGPL1, CRAT, CROTendoplasmic reticulum, cytosol, peroxisomeOne of 3 routes
tetradecanedioyl-CoAReach from here →
1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
2. Fas180
3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal
Catalysed by SGPL1, ACAA1, HSD17B4, EHHADH and 1 moreendoplasmic reticulum, cytosol, peroxisome
hexadecanedioyl-CoAReach from here →
1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
2. Fas180
3. Production of Hexadecanedioylcarnitine
Catalysed by SGPL1, CPT1A, CPT1C, CPT1Bendoplasmic reticulum, cytosolOne of 2 routes
O-dodecanoyl-R-carnitineReach from here →
1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
2. Utilized Transport
3. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
Catalysed by SGPL1, CPT1A, CPT1C, CPT1Bendoplasmic reticulum, cytosolOne of 7 routes
1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerolReach from here →
1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
2. Fas180
3. 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + octadecanoate + H(+)
Catalysed by SGPL1, ABHD11endoplasmic reticulum, cytosol
(11Z,14Z)-eicosadienoateReach from here →
1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by SGPL1endoplasmic reticulum, cytosol, extracellular spaceOne of 12 routes
(17Z)-hexacosenoateReach from here →
1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by SGPL1endoplasmic reticulum, cytosol, extracellular spaceOne of 12 routes
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoateReach from here →
1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by SGPL1endoplasmic reticulum, cytosol, extracellular spaceOne of 12 routes
(7Z,10Z,13Z,16Z)-docosatetraenoateReach from here →
1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by SGPL1endoplasmic reticulum, cytosol, extracellular spaceOne of 12 routes
pristanoyl-CoAReach from here →
1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
2. Fas180
3. fatty-acid-CoA ligase
Catalysed by SGPL1, SLC27A2endoplasmic reticulum, cytosolOne of 2 routes
2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serineReach from here →
1. 3-sn-phosphatidate phosphohydrolase
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 4 morecytosol
undecanoyl-CoAReach from here →
1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
2. Fas180
3. medium-chain acyl-CoA ligase (undecylic acid)
Catalysed by SGPL1, ACSM4, ACSM1, ACSM2A and 3 moreendoplasmic reticulum, cytosolOne of 3 routes
1-O-hexadecyl-sn-glycero-3-phosphateReach from here →
1. 3-sn-phosphatidate phosphohydrolase
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 6 morecytosol
(5Z,8Z,11Z)-eicosatrienoateReach from here →
1. sphingosine-1-phosphate lyase (sphingosine-1-phosphate)
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by SGPL1endoplasmic reticulum, cytosol, extracellular spaceOne of 12 routes
hexadecanoateReach from here →
1. 3-sn-phosphatidate phosphohydrolase
2. sphing-4-enine + hexadecanoyl-CoA = N-hexadecanoylsphing-4-enine + CoA + H(+)
3. N-hexadecanoylsphing-4-enine + H2O = sphing-4-enine + hexadecanoate
Catalysed by PLPP1, PLPP3, PLPP2, SGPP2 and 10 morecytosolOne of 2 routes