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a 1-O-alkyl-sn-glycero-3-phosphoethanolamine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

15 compounds within 3 steps: 2 in 1, 5 in 2, 8 in 3

Does it reach a compound?

One step

ethanolamineReach from here →
1. a 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)
Catalysed by ENPP2
a 1-O-alkyl-sn-glycero-3-phosphateReach from here →
1. a 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)
Catalysed by ENPP2

Two steps

acetaldehydeReach from here →
1. a 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)
2. ethanolamine ammonia-lyase (acetaldehyde-forming)
Catalysed by ENPP2cytosol
O-phosphoethanolamineReach from here →
1. a 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)
2. ATP:ethanolamine O-phosphotransferase
Catalysed by ENPP2, CHKA, ETNK1, ETNK2 and 1 morecytosol
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine

Three steps

CHEBI:16132Reach from here →
Catalysed by ENPP2, DERAcytosol
acetateReach from here →
Catalysed by ENPP2, ALDH3A1 and 1 more

Reach from here →

a 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)
fatty acylamide amidohydrolase

Catalysed by ENPP2, FAAHcytosol

phosphoethanolamineReach from here →

a 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)
ethanolamine + ATP = phosphoethanolamine + ADP + H(+)

Catalysed by ENPP2, CHKA, ETNK1, ETNK2 and 1 more

a 1-O-alkylglycerone 3-phosphateReach from here →

a 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)
a 1-O-alkylglycerone 3-phosphate + NADPH + H(+) = a 1-O-alkyl-sn-glycero-3-phosphate + NADP(+)

Catalysed by ENPP2, DHRS7B

cytosol

One of 4 routes

(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

a 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)
fatty acylamide amidohydrolase
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + H2O = ethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate

Catalysed by ENPP2, FAAH, FAAH2cytosol

CDP-ethanolamineReach from here →

a 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)
ATP:ethanolamine O-phosphotransferase
CTP:ethanolamine-phosphate cytidylyltransferase

Catalysed by ENPP2, CHKA, ETNK1, ETNK2 and 2 morecytosolOne of 3 routes

sphinganine 1-phosphateReach from here →

a 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)
ATP:ethanolamine O-phosphotransferase
Sphinganine-1-phosphate pamlmitaldehyde-lyase

Catalysed by ENPP2, CHKA, ETNK1, ETNK2 and 2 morecytosol

2-deoxy-D-ribose 5-phosphateReach from here →

a 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)
ethanolamine ammonia-lyase (acetaldehyde-forming)
2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde

Catalysed by ENPP2, DERAcytosol

2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoateReach from here →

a 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)
fatty acylamide amidohydrolase
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine

Catalysed by ENPP2, FAAH, PLA2G15cytosol

(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →

a 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)
fatty acylamide amidohydrolase
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 2-[(5Z,8Z,11Z,14Z)-eicosatetraenoylamino]ethyl (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine

Catalysed by ENPP2, FAAH, PLA2G15cytosol