a 1,2-diacyl-sn-glycerol

Three steps

• N-(2-hydroxydocosanoyl)-sphinganineReach from here →
  1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
  2. sphinganine + hexadecanoate = N-hexadecanoylsphinganine + H2O
  3. 2-hydroxydocosanoyl-CoA + sphinganine = N-(2-hydroxydocosanoyl)-sphinganine + CoA + H(+)

  Catalysed by SGMS1, SGMS2, ASAH2, CERS3 and 1 more

• N-eicosanoylsphinganineReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)
  3. eicosanoyl-CoA + sphinganine = N-eicosanoylsphinganine + CoA + H(+)

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 12 morecytosolOne of 2 routes

• N-(octadecanoyl)-sphinganineReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. sphinganine + octadecanoyl-CoA = N-(octadecanoyl)-sphinganine + CoA + H(+)

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 14 morecytosolOne of 2 routes

• N-(2-hydroxyoctadecanoyl)-sphinganineReach from here →
  1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
  2. sphinganine + hexadecanoate = N-hexadecanoylsphinganine + H2O
  3. 2-hydroxyoctadecanoyl-CoA + sphinganine = N-(2-hydroxyoctadecanoyl)-sphinganine + CoA + H(+)

  Catalysed by SGMS1, SGMS2, ASAH2, CERS1 and 1 more

• N-(2-hydroxyhexadecanoyl)-sphinganineReach from here →
  1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
  2. sphinganine + hexadecanoate = N-hexadecanoylsphinganine + H2O
  3. 2-hydroxyhexadecanoyl-CoA + sphinganine = N-(2-hydroxyhexadecanoyl)-sphinganine + CoA + H(+)

  Catalysed by SGMS1, SGMS2, ASAH2, CERS5

• N-(tetradecanoyl)-sphinganineReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. sphinganine + tetradecanoyl-CoA = N-(tetradecanoyl)-sphinganine + CoA + H(+)

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 11 morecytosolOne of 2 routes

• (22R)-hydroxycholesterolReach from here →
  1. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. 2 reduced [adrenodoxin] + cholesterol + O2 + 2 H(+) = (22R)-hydroxycholesterol + 2 oxidized [adrenodoxin] + H2O

  Catalysed by SGMS1, SGMS2, GBA1, GBA2 and 1 moreOne of 2 routes

• 3-oxohexadecasphinganineReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. tetradecanoyl-CoA + L-serine + H(+) = 3-oxohexadecasphinganine + CO2 + CoA

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 11 morecytosol

• 3-oxotetradecasphinganineReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (lauric acid)
  3. dodecanoyl-CoA + L-serine + H(+) = 3-oxotetradecasphinganine + CO2 + CoA

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 11 morecytosol

• Mo-molybdopterinReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 2 morecytosol, mitochondrial matrix

• 3-oxooctadecanoyl-CoAReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. Palmitate:CoA ligase (AMP-forming)
  3. very-long-chain 3-oxoacyl-CoA synthase (malonyl-CoA)

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 16 morecytosolOne of 2 routes

• 3-oxodocosanoyl-CoAReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)
  3. very-long-chain 3-oxoacyl-CoA synthase (eicosanoyl-CoA)

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 16 morecytosolOne of 3 routes

• 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (gamma-linolenate)
  3. (6Z,9Z,12Z)-octadecatrienoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CO2 + CoA

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 11 morecytosol

• 3-oxo-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearidonic acid)
  3. (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + CO2 + CoA

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 10 morecytosol

• N-(octacosanoyl)-sphinganineReach from here →
  1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
  2. sphinganine + hexadecanoate = N-hexadecanoylsphinganine + H2O
  3. octacosanoyl-CoA + sphinganine = N-(octacosanoyl)-sphinganine + CoA + H(+)

  Catalysed by SGMS1, SGMS2, ASAH2, CERS3

• 1-dodecanoyl-sn-glycerol 3-phosphateReach from here →
  1. 1,2-diacyl-sn-glycerol acylhydrolase
  2. ATP:acylglycerol 3-phosphotransferase
  3. 1-acylglycerol-3-phosphate pool formation and breakdown

  Catalysed by LIPF, LIPC, PNLIP, CEL and 12 moreextracellular space, cytosolOne of 3 routes

• 1-tetradecanoyl-sn-glycerol 3-phosphateReach from here →
  1. 1,2-diacyl-sn-glycerol acylhydrolase
  2. ATP:acylglycerol 3-phosphotransferase
  3. 1-acylglycerol-3-phosphate pool formation and breakdown

  Catalysed by LIPF, LIPC, PNLIP, CEL and 12 moreextracellular space, cytosolOne of 2 routes

• 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. 1,2-diacyl-sn-glycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H(+)

  Catalysed by LPL, ABHD12extracellular space

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 9 morecytosol

• 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. 1,2-diacyl-sn-glycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (9Z)-octadecenoate + H(+)

  Catalysed by LPL, ABHD16Aextracellular space

• 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (9Z,12Z)-octadecadienoyl-CoA = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 10 morecytosol

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 10 morecytosol

• 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z,12Z)-octadecadienoyl-CoA = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 10 morecytosol

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphateReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 9 morecytosol

• 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphateReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 10 morecytosol

• 1,2-dihexadecanoyl-sn-glycero-3-phosphateReach from here →
  1. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  2. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
  3. 1,2-dihexadecanoyl-sn-glycerol + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)

  Catalysed by SGMS1, SGMS2, DGKA

• N-dodecanoylsphing-4-enineReach from here →
  1. 1,2-diacyl-sn-glycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. N-dodecanoylsphing-4-enine + H2O = dodecanoate + sphing-4-enine

  Catalysed by LPL, NAAA, ASAH1, ACER2 and 1 moreextracellular spaceOne of 4 routes

• N-tetradecanoylsphing-4-enineReach from here →
  1. 1,2-diacyl-sn-glycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. N-tetradecanoylsphing-4-enine + H2O = sphing-4-enine + tetradecanoate

  Catalysed by LPL, ASAH1, ACER2, ASAH2extracellular spaceOne of 2 routes

• N-hexadecanoylsphing-4-enineReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. sphing-4-enine + hexadecanoyl-CoA = N-hexadecanoylsphing-4-enine + CoA + H(+)

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 9 morecytosol, Golgi apparatusOne of 4 routes

• N-octadecanoylsphing-4-enineReach from here →
  1. 1,2-diacyl-sn-glycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. N-octadecanoylsphing-4-enine + H2O = sphing-4-enine + octadecanoate

  Catalysed by LPL, ASAH1, ACER2, ASAH2extracellular spaceOne of 5 routes

• N-eicosanoyl-sphing-4-enineReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)
  3. eicosanoyl-CoA + sphing-4-enine = N-eicosanoyl-sphing-4-enine + CoA + H(+)

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 11 morecytosolOne of 2 routes

• N-tetracosanoyl-sphing-4-enineReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (lignocerate)
  3. tetracosanoyl-CoA + sphing-4-enine = N-tetracosanoyl-sphing-4-enine + CoA + H(+)

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 10 morecytosolOne of 2 routes

• 1-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
  3. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by SGMS1, SGMS2, GBA1, GBA2 and 1 moreOne of 9 routes

• 1,2-dihexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. ceramide:phosphatidylcholine cholinephosphotransferase
  3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin

  Catalysed by CHPT1, CEPT1, SGMS1, SGMS2cytosol, Golgi apparatusOne of 2 routes

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. octadecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 9 morecytosol

• 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 12 morecytosol

• (9Z,12Z)-octadecadien-1-olReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. (9Z,12Z)-octadecadienoyl-CoA + 2 NADPH + 2 H(+) = (9Z,12Z)-octadecadien-1-ol + 2 NADP(+) + CoA

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 10 morecytosol

• (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoAReach from here →
  1. 1,2-diacyl-sn-glycerol acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (7Z,10Z,13Z,16Z)-docosatetraenoate + ATP + CoA = (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + AMP + diphosphate

  Catalysed by LPL, ACSL4extracellular space

• 1-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. 1,2-diacyl-sn-glycerol acylhydrolase
  2. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  3. 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by LIPF, LIPC, PNLIP, CEL and 12 moreextracellular spaceOne of 2 routes

• 3-oxo-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (EPA)
  3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + CO2 + CoA

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 11 morecytosol

• (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoAReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (DPA)
  3. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + malonyl-CoA + H(+) = (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 10 morecytosol

• 3-oxooctacosanyol-CoAReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (cerotic acid)
  3. hexacosanoyl-CoA + malonyl-CoA + H(+) = 3-oxooctacosanyol-CoA + CO2 + CoA

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 11 morecytosol

• 3-oxotetracosanoyl-CoAReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (behenic acid)
  3. very-long-chain 3-oxoacyl-CoA synthase (docosanoyl-CoA)

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 16 morecytosolOne of 3 routes

• 3-oxohexacosanoyl-CoAReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (lignocerate)
  3. very-long-chain 3-oxoacyl-CoA synthase (malonyl-CoA)

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 16 morecytosolOne of 3 routes

• 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphateReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (palmitolate)
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-hexadecenoyl-CoA = 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 10 morecytosol

• 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (palmitolate)
  3. 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-hexadecenoyl-CoA = 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 10 morecytosol

• 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (palmitolate)
  3. (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 11 morecytosol

• (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoAReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. (9Z,12Z)-octadecadienoyl-CoA + malonyl-CoA + H(+) = (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 13 morecytosol

• (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoAReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (linolenate)
  3. (9Z,12Z,15Z)-octadecatrienoyl-CoA + malonyl-CoA + H(+) = (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 13 morecytosol

• 3-oxo-(13Z)-docosenoyl-CoAReach from here →
  1. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)
  3. (11Z)-eicosenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(13Z)-docosenoyl-CoA + CO2 + CoA

  Catalysed by DGAT1, MOGAT2, MOGAT3, MOGAT1 and 10 morecytosol