CHEBI:16436

Three steps

• a 1-acyl-sn-glycero-3-phosphocholineReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)

  Catalysed by SGMS1, SGMS2, PLA2G10, PLA2G6 and 28 moreendoplasmic reticulumOne of 12 routes

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)Reach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + a 1,2-diacyl-sn-glycero-3-phosphocholine(out)

  Catalysed by SGMS1, SGMS2, OSBPL3endoplasmic reticulum, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-acetylputrescineReach from here →
  1. CDP-choline:1-alkyl-2-acetylglycerol cholinephosphotransferase
  2. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  3. N-acetylputrescine + H2O = putrescine + acetate

  Catalysed by CHPT1, CEPT1, PAFAH1B1, PAFAH1B2 and 4 morecytosol

• an acyl-CoAReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. ceramide cholinephosphotransferase (CDP-choline)
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by ASAH1, ACER2, ACER1, ASAH2endoplasmic reticulum, Golgi apparatusOne of 3 routes

• N(8)-acetylspermidineReach from here →
  1. CDP-choline:1-alkyl-2-acetylglycerol cholinephosphotransferase
  2. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  3. N(8)-acetylspermidine + H2O = spermidine + acetate

  Catalysed by CHPT1, CEPT1, PAFAH1B1, PAFAH1B2 and 4 morecytosol

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. phosphatidylcholine 2-acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by CHPT1, CEPT1, PLA2G10, PLA2G6 and 16 morecytosol, endoplasmic reticulum, extracellular spaceOne of 12 routes

• a 1,2-diacyl-sn-glycero-3-phosphateReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. ceramide:phosphatidylcholine cholinephosphotransferase
  3. a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)

  Catalysed by CHPT1, CEPT1, SGMS1, SGMS2 and 11 morecytosol, Golgi apparatusOne of 2 routes

• an N-acetyl-L-cysteine-S-conjugateReach from here →
  1. CDP-choline:1-alkyl-2-acetylglycerol cholinephosphotransferase
  2. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
  3. an N-acetyl-L-cysteine-S-conjugate + H2O = an S-substituted L-cysteine + acetate

  Catalysed by CHPT1, CEPT1, PAFAH1B1, PAFAH1B2 and 4 morecytosol

• CDP-cholineReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. a sphingomyelin + H2O = phosphocholine + an N-acylsphing-4-enine + H(+)
  3. phosphocholine + CTP + H(+) = CDP-choline + diphosphate

  Catalysed by SMPD2, SMPD1, ENPP7, SMPD4 and 3 moreendoplasmic reticulumOne of 2 routes

• a cardiolipinReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by SGMS1, SGMS2, TAFAZZINendoplasmic reticulum

• an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acyl-sn-glycero-3-phosphocholine + H(+)

  Catalysed by SGMS1, SGMS2, PLA2G4E, PLAAT5 and 1 moreendoplasmic reticulumOne of 2 routes

• hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
  3. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+)

  Catalysed by SGMS2, PLAAT3, PLAAT1endoplasmic reticulumOne of 2 routes

• a 1,2-diacyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. ceramide:phosphatidylcholine cholinephosphotransferase
  3. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)

  Catalysed by CHPT1, CEPT1, SGMS1, SGMS2 and 1 morecytosol, Golgi apparatus

• a triacyl-sn-glycerolReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. ceramide:phosphatidylcholine cholinephosphotransferase
  3. an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA

  Catalysed by CHPT1, CEPT1, SGMS1, SGMS2 and 6 morecytosol, Golgi apparatus

• N-hexadecanoyl-(4R)-hydroxysphinganineReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. ceramide:phosphatidylcholine cholinephosphotransferase
  3. N-hexadecanoyl-(4R)-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine + a 1,2-diacyl-sn-glycerol

  Catalysed by CHPT1, CEPT1, SGMS1, SGMS2cytosol, Golgi apparatus

• N-hexadecanoylsphinganineReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. ceramide:phosphatidylcholine cholinephosphotransferase
  3. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol

  Catalysed by CHPT1, CEPT1, SGMS1, SGMS2cytosol, Golgi apparatus

• an N-acylsphinganine-1-phosphocholineReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol

  Catalysed by SGMS1, SGMS2endoplasmic reticulum

• (8Z,11Z,14Z)-eicosatrienoateReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. phosphatidylcholine 2-acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by CHPT1, CEPT1, PLA2G10, PLA2G6 and 16 morecytosol, endoplasmic reticulum, extracellular spaceOne of 12 routes

• 1,2-dihexadecanoyl-sn-glycero-3-phosphateReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
  3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)

  Catalysed by SGMS2, PLD2, PLD1endoplasmic reticulum

• 1-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
  3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)

  Catalysed by SGMS2, PLA2G10, PLA2G6, PLA2G1B and 11 moreendoplasmic reticulumOne of 4 routes

• 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
  3. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by SGMS2, TAFAZZINendoplasmic reticulum

• an N-acylsphing-4-enine 1-phosphoethanolamineReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. ceramide cholinephosphotransferase (CDP-choline)
  3. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphing-4-enine 1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

  Catalysed by SGMS1, SGMS2, SAMD8endoplasmic reticulum

• 2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
  3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)

  Catalysed by SGMS2, PLAAT3, PLA2G15, PLAAT1 and 2 moreendoplasmic reticulumOne of 6 routes

• 1-O-alkyl-3-acylglycerolReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. 1-O-alkylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-alkyl-3-acylglycerol + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by SGMS1, SGMS2, PLA2G15endoplasmic reticulumOne of 2 routes

• 1-O-alkyl-2,3-diacyl-sn-glycerolReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. 1-O-alkyl-2-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-alkyl-2,3-diacyl-sn-glycerol + a 2-acyl-sn-glycero-3-phosphocholine

  Catalysed by SGMS1, SGMS2, PLA2G15endoplasmic reticulumOne of 2 routes

• (11Z,14Z)-eicosadienoateReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. phosphatidylcholine 2-acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by CHPT1, CEPT1, PLA2G10, PLA2G6 and 16 morecytosol, endoplasmic reticulum, extracellular spaceOne of 12 routes

• (17Z)-hexacosenoateReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. phosphatidylcholine 2-acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by CHPT1, CEPT1, PLA2G10, PLA2G6 and 16 morecytosol, endoplasmic reticulum, extracellular spaceOne of 12 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoateReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. phosphatidylcholine 2-acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by CHPT1, CEPT1, PLA2G10, PLA2G6 and 16 morecytosol, endoplasmic reticulum, extracellular spaceOne of 12 routes

• (7Z,10Z,13Z,16Z)-docosatetraenoateReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. phosphatidylcholine 2-acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by CHPT1, CEPT1, PLA2G10, PLA2G6 and 16 morecytosol, endoplasmic reticulum, extracellular spaceOne of 12 routes

• a 1,3-diacyl-sn-glycerolReach from here →
  1. diacylglycerol cholinephosphotransferase (1-alkyl-2-acylglycerol)
  2. a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
  3. a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)

  Catalysed by CHPT1, CEPT1, PLA2G6, PLA2G4A and 5 morecytosol

• a 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
  3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine = a 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by SGMS2, PLAAT1endoplasmic reticulum

• a fatty acyl-CoAReach from here →
  1. diacylglycerol cholinephosphotransferase (1-alkyl-2-acylglycerol)
  2. a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
  3. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate

  Catalysed by CHPT1, CEPT1, PLA2G6, PLA2G4A and 5 morecytosol

• (5Z,8Z,11Z)-eicosatrienoateReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. phosphatidylcholine 2-acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by CHPT1, CEPT1, PLA2G10, PLA2G6 and 16 morecytosol, endoplasmic reticulum, extracellular spaceOne of 12 routes

• N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
  3. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+)

  Catalysed by SGMS2, PLAAT3, PLAAT1endoplasmic reticulumOne of 3 routes

• N-hexadecanoyl-sphinganine-1-phosphocholineReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol

  Catalysed by SGMS1, SGMS2endoplasmic reticulum

• N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholineReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. N-hexadecanoyl-(4R)-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine + a 1,2-diacyl-sn-glycerol

  Catalysed by SGMS1, SGMS2endoplasmic reticulum

• an N-acyl-(4R)-4-hydroxysphinganine-phosphocholineReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. an N-acyl-(4R)-4-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine + a 1,2-diacyl-sn-glycerol

  Catalysed by SGMS1, SGMS2endoplasmic reticulum

• hexadecanoateReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
  3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)

  Catalysed by SGMS2, PLAAT3, PLA2G15, PLAAT1 and 2 moreendoplasmic reticulumOne of 4 routes

• tricosanoateReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. phosphatidylcholine 2-acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by CHPT1, CEPT1, PLA2G10, PLA2G6 and 16 morecytosol, endoplasmic reticulum, extracellular spaceOne of 12 routes

• cholesteryl octadecanoateReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. Phosphatidylcholine:sterol O-acyltransferase
  3. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion

  Catalysed by CHPT1, CEPT1, LCATcytosol, lysosomeOne of 4 routes

• 1,2-dihexadecanoyl-sn-glycerolReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. ceramide cholinephosphotransferase (CDP-choline)
  3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin

  Catalysed by SGMS2endoplasmic reticulumOne of 3 routes

• 1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerolReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. ceramide cholinephosphotransferase (CDP-choline)
  3. 1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin = a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine

  Catalysed by SGMS1, SGMS2endoplasmic reticulumOne of 2 routes

• cholesteryl (8Z,11Z,14Z)-eicosatrienoateReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. Phosphatidylcholine:sterol O-acyltransferase
  3. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion

  Catalysed by CHPT1, CEPT1, LCATcytosol, lysosomeOne of 4 routes

• a monoacyl-sn-glycero-3-phosphocholineReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a monoacyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)

  Catalysed by SGMS1, SGMS2, PNLIPRP2endoplasmic reticulum

• 2-(acylamino)ethyl fatty acidReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. an N-acylethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine = 2-(acylamino)ethyl fatty acid + a 2-acyl-sn-glycero-3-phosphocholine

  Catalysed by SGMS1, SGMS2, PLA2G15endoplasmic reticulumOne of 2 routes

• 1-O-acyl-N-(acetyl)-sphing-4-enineReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. N-(acetyl)-sphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine

  Catalysed by SGMS1, SGMS2, PLA2G15endoplasmic reticulumOne of 2 routes

• 1,2-diacyl-sn-glycero-3-phosphoethanolReach from here →
  1. ceramide cholinephosphotransferase (CDP-choline)
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. ethanol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1,2-diacyl-sn-glycero-3-phosphoethanol + choline

  Catalysed by SGMS1, SGMS2, PLD1endoplasmic reticulum

• (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterolReach from here →
  1. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  2. Phosphatidylcholine:sterol O-acyltransferase
  3. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion

  Catalysed by CHPT1, CEPT1, LCATcytosol, lysosomeOne of 4 routes