Catalyst

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Search ?

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

Reach

leukotriene F4

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

410 compounds within 3 steps: 4 in 1, 55 in 2, 351 in 3

Does it reach a compound?

Two steps

prostaglandin E2Reach from here →
1. transport of leukotriene F4 (cytosol to extracellular)
2. transport of prostaglandin E2 (cytosol to extracellular)
Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes
L-cysteinylglycineReach from here →
1. transport of GSH and leukotriene F4 (cytosol to extracellular)
2. glutathione gamma-glutamylaminopeptidase
Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 2 moreextracellular space, cytosolOne of 4 routes
leukotriene D4Reach from here →
1. leukotriene C4 hydrolysis
2. leukotriene C4 + H2O = leukotriene D4 + L-glutamate
Catalysed by GGT1, GGT5cytosol
(R)-noradrenalineReach from here →
1. transport of leukotriene F4 (cytosol to extracellular)
2. transport of noradrenaline (cytosol to extracellular)
Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes
20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. transport of leukotriene F4 (cytosol to extracellular)
2. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes
ursodeoxycholateReach from here →
1. transport of leukotriene F4 (cytosol to extracellular)
2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
Catalysed by SLCO1B1, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes
prostaglandin G2Reach from here →
1. transport of leukotriene F4 (cytosol to extracellular)
2. transport of prostaglandin G2 (cytosol to extracellular)
Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes
thromboxane B2Reach from here →
1. transport of leukotriene F4 (cytosol to extracellular)
2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes
taurochenodeoxycholateReach from here →
1. transport of leukotriene F4 (cytosol to extracellular)
2. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)
Catalysed by SLCO1B1, SLCO1A2, SLC7A9, SLCO1B3extracellular space, cytosolOne of 4 routes

Three steps

(S)-carnitineReach from here →
Catalysed by SLCO1B1extracellular space, cytosol, endoplasmic reticulumOne of 246 routes
N(omega)-methyl-L-arginineReach from here →
Catalysed by AGXT2cytosol

Page 2 of 9

(5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate

Reach from here →

transport of GSH and leukotriene F4 (cytosol to extracellular)
Glutathione: 15-HPETE oxidoreductase
(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 moreextracellular space, cytosol

2-phenylpropan-2-olReach from here →

leukotriene C4 hydrolysis
leukotriene C4 = leukotriene A4 + glutathione
cumene hydroperoxide + 2 glutathione = 2-phenylpropan-2-ol + glutathione disulfide + H2O

Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 4 morecytosol

a hydroxy polyunsaturated fatty acidReach from here →

leukotriene C4 hydrolysis
leukotriene C4 = leukotriene A4 + glutathione
a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O

Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 3 morecytosol

AReach from here →

transport of leukotriene F4 (cytosol to extracellular)
transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, DIO1 and 1 moreextracellular space, cytosolOne of 8 routes

(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →

transport of leukotriene F4 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP1A1, CYP1A2, CYP3A4 and 5 moreextracellular space, cytosol

(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →

transport of leukotriene F4 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP1A1, CYP1A2, CYP3A4 and 5 moreextracellular space, cytosol

(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →

transport of leukotriene F4 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP2C8, CYP2C9, CYP2C19 and 2 moreextracellular space, cytosol

(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →

transport of leukotriene F4 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP1A1, CYP2C8, CYP2D6 and 4 moreextracellular space, cytosol

(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →

transport of leukotriene F4 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP2C9, CYP2J2extracellular space, cytosol

(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →

transport of leukotriene F4 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP1A1, CYP2D6, CYP2C9 and 3 moreextracellular space, cytosol

5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoateReach from here →

transport of leukotriene F4 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by SLCO1B1, CYP1A1, CYP1A2, CYP2E1 and 23 moreextracellular space, cytosolOne of 4 routes

17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

transport of leukotriene F4 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by SLCO1B1, CYP1A1, CYP1A2, CYP2E1 and 23 moreextracellular space, cytosolOne of 2 routes

16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

transport of leukotriene F4 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP1A1extracellular space, cytosol

(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →

leukotriene C4 hydrolysis
leukotriene C4 = leukotriene A4 + glutathione
(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + glutathione disulfide + H2O

Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 2 morecytosol

10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

transport of leukotriene F4 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP3A4, CYP2C9extracellular space, cytosol

prostaglandin J2Reach from here →

transport of leukotriene F4 (cytosol to extracellular)
transport of prostaglandin D2 (cytosol to extracellular)
prostaglandin J2 hydrolysis

Catalysed by SLCO1B1extracellular space, cytosolOne of 2 routes

15-oxoprostaglandin F2alphaReach from here →

transport of leukotriene F4 (cytosol to extracellular)
transport of prostaglandin F2alpha (cytosol to extracellular)
15-keto-prostaglandin F2alpha reduction

Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes

dopamine 3-O-sulfateReach from here →

transport of leukotriene F4 (cytosol to extracellular)
transport of dopamine (cytosol to extracellular)
dopamine + 3'-phosphoadenylyl sulfate = dopamine 3-O-sulfate + adenosine 3',5'-bisphosphate + H(+)

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT1B1 and 3 moreextracellular space, cytosol

dopamine 4-O-sulfateReach from here →

transport of leukotriene F4 (cytosol to extracellular)
transport of dopamine (cytosol to extracellular)
Dopamine 4-O-Sulfotransferase

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT1A3 and 1 moreextracellular space, cytosolOne of 2 routes

hyocholateReach from here →

transport of leukotriene F4 (cytosol to extracellular)
solute carrier organic anion transporter (chenodiol)
Chenodeoxycholic acid 6alpha-hydroxylase

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, CYP3A4extracellular space, cytosol

prostaglandin A2-S-(R)-glutathioneReach from here →

transport of leukotriene F4 (cytosol to extracellular)
transport of prostaglandin A2 (cytosol to extracellular)
prostaglandin A2 + glutathione = prostaglandin A2-S-(R)-glutathione

Catalysed by SLCO1B1, GSTA1, GSTM1extracellular space, cytosolOne of 2 routes

prostaglandin A2-S-(S)-glutathioneReach from here →

transport of leukotriene F4 (cytosol to extracellular)
transport of prostaglandin A2 (cytosol to extracellular)
prostaglandin A2 + glutathione = prostaglandin A2-S-(S)-glutathione

Catalysed by SLCO1B1, GSTP1, GSTM1extracellular space, cytosolOne of 2 routes

prostaglandin J2-S-(R)-glutathioneReach from here →

leukotriene C4 hydrolysis
leukotriene C4 = leukotriene A4 + glutathione
prostaglandin J2 + glutathione = prostaglandin J2-S-(R)-glutathione

Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 3 morecytosol

prostaglandin J2-S-(S)-glutathioneReach from here →

leukotriene C4 hydrolysis
leukotriene C4 = leukotriene A4 + glutathione
prostaglandin J2 + glutathione = prostaglandin J2-S-(S)-glutathione

Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 2 morecytosol

(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoateReach from here →

transport of leukotriene F4 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate

Catalysed by SLCO1B1, ALOX15extracellular space, cytosol

(14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoateReach from here →

transport of leukotriene F4 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate

Catalysed by SLCO1B1, ALOX15extracellular space, cytosol

N-(9Z-octadecenoyl)glycineReach from here →

leukotriene C4 hydrolysis
leukotriene C4 hydrolysis
(9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)

Catalysed by GLYATL3, GLYATL2cytosol

N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →

transport of leukotriene F4 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O

Catalysed by SLCO1B1, PM20D1extracellular space, cytosol

N-octadecanoylglycineReach from here →

leukotriene C4 hydrolysis
leukotriene C4 hydrolysis
octadecanoyl-CoA + glycine = N-octadecanoylglycine + CoA + H(+)

Catalysed by GLYATL2cytosol

N-(9Z-hexadecenoyl)-glycineReach from here →

leukotriene C4 hydrolysis
leukotriene C4 hydrolysis
(9Z)-hexadecenoyl-CoA + glycine = N-(9Z-hexadecenoyl)-glycine + CoA + H(+)

Catalysed by GLYATL2cytosol

7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

transport of leukotriene F4 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by SLCO1B1, CYP1A1, CYP1A2, CYP2E1 and 23 moreextracellular space, cytosolOne of 2 routes

13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

transport of leukotriene F4 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by SLCO1B1, CYP1A1, CYP1A2, CYP2E1 and 23 moreextracellular space, cytosolOne of 2 routes

13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

transport of leukotriene F4 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by SLCO1B1, CYP2C9extracellular space, cytosol

chenodeoxycholoyl-24-O-(beta-D-glucuronate)Reach from here →

transport of leukotriene F4 (cytosol to extracellular)
solute carrier organic anion transporter (chenodiol)
chenodeoxycholate + UDP-alpha-D-glucuronate = chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, UGT2A2 and 1 moreextracellular space, cytosol

16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →

transport of leukotriene F4 (cytosol to extracellular)
transport of arachidonate (cytosol to extracellular)
unspecific monooxygenase (arachidonate)

Catalysed by SLCO1B1, CYP1A1, CYP1A2, CYP2E1 and 23 moreextracellular space, cytosol

(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoateReach from here →

leukotriene C4 hydrolysis
leukotriene C4 = leukotriene A4 + glutathione
(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione = (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate

Catalysed by MGST3, GSTM4, LTC4S, MGST2cytosol

N-(4-oxoglutaryl)-L-cysteinylglycineReach from here →

transport of GSH and leukotriene F4 (cytosol to extracellular)
glutathione gamma-glutamylaminopeptidase
N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate

Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 moreextracellular space, cytosol

S-methyl glutathioneReach from here →

leukotriene C4 hydrolysis
leukotriene C4 = leukotriene A4 + glutathione
apo-[alkylcobalamin reductase] + methylcob(III)alamin + glutathione = S-methyl glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)

Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 1 morecytosol

beta-D-glucosyl-(1->3)-O-chenodeoxycholateReach from here →

transport of leukotriene F4 (cytosol to extracellular)
solute carrier organic anion transporter (chenodiol)
a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + chenodeoxycholate = beta-D-glucosyl-(1->3)-O-chenodeoxycholate + a di-trans,poly-cis-dolichyl phosphate + H(+)

Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, GBA2extracellular space, cytosolOne of 2 routes