Compound
candesartan
A monocarboxylic acid anion resulting from the deprotonation of the tetrazole NH group and carboxy group of candesartan. It is the major species at pH 7.3.
Definition from ChEBI (CHEBI:149509), read 2026-09-23. CC BY 4.0.
Structure
Loading the model…
- Class
- Organic compound, anion
- Formula
- C24H18N6O3
- Mass
- 438.447 g/mol
- Charge
- -2
- InChIKey
- BSLSLQSFLOCXQQ-UHFFFAOYSA-L
- SMILES
- CCOc1nc2cccc(C(=O)[O-])c2n1Cc1ccc(-c2ccccc2-c2nnn[n-]2)cc1
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
6 entities
6 entities reached.
0 reported hops6 assembled from the scaffold
- UGT2B7ProteinUNIPROT:P16662metabolized byInferred only32 paths16 endpoints
- UGT1A10ProteinUNIPROT:Q9HAW8metabolized byInferred only28 paths14 endpoints
- UGT1A9ProteinUNIPROT:O60656metabolized byInferred only24 paths24 endpoints
- UGT1A3ProteinUNIPROT:P35503metabolized byInferred only15 paths15 endpoints
- UGT1A7ProteinUNIPROT:Q9HAW7metabolized byInferred only12 paths12 endpoints
- UGT1A8ProteinUNIPROT:Q9HAW9metabolized byInferred only11 paths11 endpoints
What the reference databases state
Regulatory determinations
LiverTox likelihood score CLiverTox
LiverTox Likelihood Score C — probably linked to idiosyncratic liver injury, reported uncommonly. Chapter: "Candesartan". Source: LiverTox Master List (NBK571102).
The document·Public Domain (NLM/NIH)·Transcribed, not assessed
Statements
10 statements
10 statements · 1 reference database · Subject: candesartan · Sources: Rhea
- candesartan is converted to candesartan O-beta-D-glucuronosideCompoundRhea RHEA:63724Inferred only
- candesartan is converted to candesartan-2-N-beta-D-glucuronideCompoundRhea RHEA:63728Inferred only
- candesartan is metabolised by UGT1A10ProteinRhea RHEA:63728Inferred only
- candesartan is metabolised by UGT1A10ProteinRhea RHEA:63724Inferred only
- candesartan is metabolised by UGT1A3ProteinRhea RHEA:63728Inferred only
- candesartan is metabolised by UGT1A7ProteinRhea RHEA:63724Inferred only
- candesartan is metabolised by UGT1A8ProteinRhea RHEA:63724Inferred only
- candesartan is metabolised by UGT1A9ProteinRhea RHEA:63724Inferred only
- candesartan is metabolised by UGT2B7ProteinRhea RHEA:63724Inferred only
- candesartan is metabolised by UGT2B7ProteinRhea RHEA:63728Inferred only
Reactions
2 reactions
candesartan+UDP-alpha-D-glucuronatecandesartan O-beta-D-glucuronoside+UDP
Catalysed by UGT1A9 or UGT2B7 or UGT1A7 or UGT1A10 or UGT1A8
Reaction pageLeft to rightBalanced
Rhea RHEA:63724CC BY 4.0Reference data
candesartan+UDP-alpha-D-glucuronatecandesartan-2-N-beta-D-glucuronide+UDP
Catalysed by UGT2B7 or UGT1A3 or UGT1A10
Reaction pageLeft to rightBalanced
Rhea RHEA:63728CC BY 4.0Reference data
Other names
1 name
Resolves to: candesartan
- Systematic name
- 2-ethoxy-1-{[2'-(tetrazol-1-id-5-yl)[biphenyl]-4-yl]methyl}-1H-benzimidazole-7-carboxylate