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Proteins/UNIPROT:P58753
Adapter involved in TLR2, TLR4 and RAGE signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF (TNF) and interleukin-6 (IL6)..
Function from UniProtKB (P58753), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
173 statements
173 statements · 4 reference databases · Subject: TIRAP · Sources: gene ontology, Hetionet, Reactome, WikiPathways
5 names
Resolves to: TIRAP