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Proteins/UNIPROT:Q9UIG8
Putative organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormone L-thyroxine, prostanoids such as prostaglandin E1 and E2, bile acids such as taurocholate, glycolate and glycochenodeoxycholate and peptide hormones such as L-arginine vasopressin, likely operating in a tissue-specific manner. The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable). Mediates transport of tryptophan, phenyalanine and tyrosine..
[Isoform 1]: Mediates transport of steroid hormone precursors dehydroepiandrosterone 3-sulfate and estrone 3-sulfate..
[Isoform 2]: Mediates transport of steroid hormone precursors dehydroepiandrosterone 3-sulfate and estrone 3-sulfate..
[Isoform 5]: Mediates transport of steroid hormone precursors dehydroepiandrosterone 3-sulfate and estrone 3-sulfate..
Function from UniProtKB (Q9UIG8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
31 statements
31 statements · 6 reference databases · Subject: SLCO3A1 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Rhea, WikiPathways
18 reactions
Transported by SLCO4A1 or SLCO1B1 or SLCO1C1 or SLC16A2 or SLCO3A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06055CC BY 4.0Reference data
hydrogencarbonate+prostaglandin E2hydrogencarbonate+prostaglandin E2
Transported by SLCO1A2 or
11 names
Resolves to: SLCO3A1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR06101CC BY 4.0Reference data
estrone 3-sulfate+hydrogencarbonateestrone 3-sulfate+hydrogencarbonate
Transported by SLCO1A2 or SLCO4A1 or SLCO1B3 or SLCO1B1 or SLCO2B1 or SLCO1C1 or SLCO3A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06129CC BY 4.0Reference data
prostaglandin E2prostaglandin E2
Transported by SLC22A2 or SLC22A3 or SLCO2A1 or SLC22A1 or SLCO3A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06246CC BY 4.0Reference data
prostaglandin E1prostaglandin E1
Transported by SLCO2A1 or SLCO3A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06268CC BY 4.0Reference data
L-phenylalanineL-phenylalanine
Transported by SLC43A1 or SLC7A5 or SLC43A2 or SLC16A10 or SLCO3A1
Reaction pageReversibleBalanced
Rhea RHEA:27950CC BY 4.0Reference data
prostaglandin E1prostaglandin E1
Transported by SLCO3A1
Reaction pageLeft to rightBalanced
Rhea RHEA:50980CC BY 4.0Reference data
prostaglandin E2prostaglandin E2
Transported by SLC22A2 or SLC22A1 or SLCO2B1 or SLCO1A2 or SLC51A or SLC51B or SLCO2A1 or SLCO4A1 or SLCO1B3 or SLC22A11 or SLCO3A1 or SLC22A7 and 1 more alternative
Reaction pageLeft to rightBalanced
Rhea RHEA:50984CC BY 4.0Reference data
prostaglandin F2alphaprostaglandin F2alpha
Transported by SLC22A2 or SLC22A1 or SLC22A11 or SLCO3A1 or SLC22A7
Reaction pageLeft to rightBalanced
Rhea RHEA:50988CC BY 4.0Reference data
Transported by SLC7A5 or SLC38A9 or SLC16A10 or SLCO3A1
Reaction pageReversibleBalanced
Rhea RHEA:68572CC BY 4.0Reference data
Transported by SLC7A5 or SLC36A4 or SLC16A10 or SLCO3A1
Reaction pageReversibleBalanced
Rhea RHEA:70947CC BY 4.0Reference data
(5Z,8Z,11Z,14Z)-eicosatetraenoate(5Z,8Z,11Z,14Z)-eicosatetraenoate
Transported by CD36 or SLC27A1 or SLCO3A1
Reaction pageLeft to rightBalanced
Rhea RHEA:71395CC BY 4.0Reference data