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Proteins/UNIPROT:Q8IWA5

SLC44A2

Protein·UNIPROT:Q8IWA5Choline transporter-like protein 21 compound

Open in the graph

[Isoform 1]: Choline/H+ antiporter, mainly in mitochondria. Also acts as a low-affinity ethanolamine/H+ antiporter, regulating the supply of extracellular ethanolamine (Etn) for the CDP-Etn pathway, redistribute intracellular Etn and balance the CDP-Cho and CDP-Etn arms of the Kennedy pathway..

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[Isoform 3]: Does not exhibit choline transporter activity..

Function from UniProtKB (Q8IWA5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 1 · transported by

Inferred

Assembled routes, not reported.

What routes through it

1 compound

1 compound.

0 reported routes1 assembled route

cholineCompoundCHEBI:15354Inferred only148 paths74 endpoints

What the reference databases state

Statements

96 statements

96 statements · 6 reference databases · Subject: SLC44A2 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea

Search this listOrder

SLC2A7 covaries with SLC44A2ProteinHetionet hetionet:covaries:155184-57153Inferred only
SLC44A2 is expressed in adult mammalian kidneyAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in amygdalaAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in aortaAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in apex of heartAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in ascending aortaAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in bloodAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in body of stomachAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in bone marrow cellCell typeBgee ENSG00000129353Inferred only
SLC44A2 is expressed in C1 segment of cervical spinal cordAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in cardiac atriumAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in cardiac muscle of right atriumAnatomyBgee ENSG00000129353Inferred only

Show the remaining 84

SLC44A2 is expressed in cardiac ventricleAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in caudate nucleusAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in colonic epitheliumAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in coronary arteryAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in cortex of kidneyAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in descending thoracic aortaAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in endocervixAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in esophagusAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in esophagus mucosaAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in fundus of stomachAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in gallbladderAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in gastrocnemiusAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in granulocyteCell typeBgee ENSG00000129353Inferred only
SLC44A2 is expressed in heartAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in heart left ventricleAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in hindlimb stylopod muscleAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in left coronary arteryAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in left fallopian tubeAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in left lobe of thyroid glandAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in left testisAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in leukocyteCell typeBgee ENSG00000129353Inferred only
SLC44A2 is expressed in lungAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in lymph nodeAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in minor salivary glandAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in monocyteCell typeBgee ENSG00000129353Inferred only
SLC44A2 is expressed in mouth mucosaAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in mucosa of stomachAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in mucosa of transverse colonAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in nasal cavity epitheliumAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in nucleus accumbensAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in olfactory segment of nasal mucosaAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in peritoneumAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in popliteal arteryAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in putamenAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in rectumAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in right atrium auricular regionAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in right coronary arteryAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in right frontal lobeAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in right hemisphere of cerebellumAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in right lobe of thyroid glandAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in right lungAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in right testisAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in skin of legAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in small intestine Peyer's patchAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in smooth muscle tissueAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in spinal cordAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in spleenAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in stomachAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in stromal cell of endometriumCell typeBgee ENSG00000129353Inferred only
SLC44A2 is expressed in subcutaneous adipose tissueAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in sural nerveAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in testisAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in thoracic aortaAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in thyroid glandAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in tibial nerveAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in transverse colonAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in upper arm skinAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in upper lobe of left lungAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in upper lobe of lungAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in uterine cervixAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in vaginaAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in vermiform appendixAnatomyBgee ENSG00000129353Inferred only
SLC44A2 is expressed in zone of skinAnatomyBgee ENSG00000129353Inferred only
UBC interacts with SLC44A2ProteinHetionet hetionet:interacts:57153-7316Inferred only
SLC44A2 participates in Choline catabolismPathwayReactome R-HSA-6798163Inferred only
SLC44A2 participates in Glycerophospholipid biosynthesisPathwayReactome R-HSA-1483206Inferred only
SLC44A2 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
SLC44A2 participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
SLC44A2 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
SLC44A2 participates in Metabolism of amino acids and derivativesPathwayReactome R-HSA-71291Inferred only
SLC44A2 participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
SLC44A2 participates in Neutrophil degranulationPathwayReactome R-HSA-6798695Inferred only
SLC44A2 participates in Phospholipid metabolismPathwayReactome R-HSA-1483257Inferred only
SLC44A2 participates in SLC-mediated bile acid transportPathwayReactome R-HSA-9958517Inferred only
SLC44A2 participates in SLC-mediated transmembrane transportPathwayReactome R-HSA-425407Inferred only
SLC44A2 participates in SLC-mediated transport of organic anionsPathwayReactome R-HSA-9955298Inferred only
SLC44A2 participates in Synthesis of PCPathwayReactome R-HSA-1483191Inferred only
SLC44A2 participates in Transport of small moleculesPathwayReactome R-HSA-382551Inferred only
SLC44A2 regulates positive regulation of canonical NF-kappaB signal transductionBiological processgene ontology Q8IWA5|GO:0043123Inferred only
choline is transported by SLC44A2CompoundHuman-GEM MAR04954Inferred only
choline is transported by SLC44A2CompoundRhea RHEA:75463Inferred only
ethanolamine is transported by SLC44A2CompoundRhea RHEA:75467Inferred only
hydron is transported by SLC44A2CompoundRhea RHEA:75463Inferred only
hydron is transported by SLC44A2CompoundRhea RHEA:75467Inferred only

Reactions

3 reactions

cholinecholine
Transported by SLC44A1 or SLC22A2 or SLC44A2 or SLC44A5 or SLC44A3 or SLC22A1 or SLC22A5 or SLC44A4
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR04954CC BY 4.0Reference data
choline+nhydroncholine+

Other names

3 names

Resolves to: SLC44A2

Also called: Choline transporter-like protein 2CTL2Solute carrier family 44 member 2

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Transported by SLC44A4 or SLC44A2 or SLC44A5 or SLC44A1

Reaction pageDirection not assertedBalance undeterminable

Rhea RHEA:75463CC BY 4.0Reference data

ethanolamine+nhydronethanolamine+nhydron

Transported by SLC44A2 or SLC44A1

Reaction pageDirection not assertedBalance undeterminable

Rhea RHEA:75467CC BY 4.0Reference data