RHOJ GTPase cycle

This pathway catalogues RHOJ (also known as TCL or RHOI) guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs), and RHOJ effectors. No GDP dissociation inhibitors (GDIs) have been shown to interact with RHOJ. RHOJ, together with RHOQ (TC10), belongs to the CDC42 subfamily of RHO GTPases and shares 85% and 78% amino acid similarity with RHOQ and CDC42, respectively. RHOJ regulates the cytoskeleton, including formation of lamellipodia and actin filaments. RHOJ is highly expressed in endothelial cells, regulating their motility and, consequently, vascular morphogenesis. As a part of the VEGF signaling cascade, RHOJ promotes retinal angiogenesis. RHOJ plays a role in cancer cell migration and cancer-related angiogenesis. RHOJ is involved in adipocyte differentiation.

Summary from Reactome (R-HSA-9013409), read 2026-09-23.