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Proteins/UNIPROT:Q96KA5
Scramblase that mediates the translocation of glucosaminylphosphatidylinositol (alpha-D-GlcN-(1-6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol, GlcN-PI) across the endoplasmic reticulum (ER) membrane, from the cytosolic leaflet to the luminal leaflet of the ER membrane, where it participates in the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is a lipid glycoconjugate involved in post-translational modification of proteins. Can also translocate 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) (phosphatidylinositol or PI), as well as several other phospholipids (1,2-diacyl-sn-glycero-3-phosphocholine, 1,2-diacyl-sn-glycero-3-phosphoethanolamine), and N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI) in vitro..
Function from UniProtKB (Q96KA5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
125 statements
125 statements · 4 reference databases · Subject: CLPTM1L · Sources: Bgee, Hetionet, Rhea, WikiPathways
5 reactions
a 1,2-diacyl-sn-glycero-3-phosphocholinea 1,2-diacyl-sn-glycero-3-phosphocholine
Transported by ANO9 or PLSCR1 or VDAC1 or VDAC2 or PITPNB or PLTP or MTTP or PITPNA or SERINC3 or ANO4 or ANO6 or TMEM41B and 14 more alternatives
Reaction pageReversibleBalance undeterminable
Rhea RHEA:38571CC BY 4.0Reference data
5 names
Resolves to: CLPTM1L
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)
Transported by PITPNM1 or VDAC2 or PITPNB or PLTP or PITPNA or CLPTM1L or PITPNM2 or PITPNC1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:38691CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phosphoethanolaminea 1,2-diacyl-sn-glycero-3-phosphoethanolamine
Transported by PLSCR1 or PLTP or MTTP or SERINC3 or ATG2A or TMEM41B or ATG9B or ATG9A or SERINC5 or ATG2B or VMP1 or CLPTM1L and 2 more alternatives
Reaction pageReversibleBalance undeterminable
Rhea RHEA:38895CC BY 4.0Reference data
a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositola 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol
Transported by CLPTM1L
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:71491CC BY 4.0Reference data
CHEBI:190691CHEBI:190691
Transported by CLPTM1L
Reaction pageDirection not assertedBalanced
Rhea RHEA:71495CC BY 4.0Reference data