Proteins/UNIPROT:Q9NVN8

GNL3L

ProteinUNIPROT:Q9NVN8

Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP..

Function from UniProtKB (Q9NVN8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

22 statements

22 statements · 3 reference databases · Subject: GNL3L · Sources: gene ontology, Hetionet, WikiPathways

Order

GNL3L covaries with COX6A2ProteinHetionet hetionet:covaries:1339-54552Inferred only
GNL3L covaries with DTX3ProteinHetionet hetionet:covaries:196403-54552Inferred only
GNL3L covaries with FAM171A2ProteinHetionet hetionet:covaries:284069-54552Inferred only
GNL3L covaries with GJC1ProteinHetionet hetionet:covaries:10052-54552Inferred only
GNL3L covaries with HDAC5ProteinHetionet hetionet:covaries:10014-54552Inferred only
GNL3L covaries with HES6ProteinHetionet hetionet:covaries:54552-55502Inferred only
GNL3L covaries with KLHL40ProteinHetionet hetionet:covaries:131377-54552Inferred only
GNL3L covaries with NDNProteinHetionet hetionet:covaries:4692-54552Inferred only
GNL3L covaries with OR5K1ProteinHetionet hetionet:covaries:26339-54552Inferred only
GNL3L covaries with XAB2ProteinHetionet hetionet:covaries:54552-56949Inferred only
LDOC1 interacts with GNL3LProteinHetionet hetionet:interacts:23641-54552Inferred only
TERF1 interacts with GNL3LProteinHetionet hetionet:interacts:54552-7013Inferred only

Show the remaining 10

UBC interacts with GNL3LProteinHetionet hetionet:interacts:54552-7316Inferred only
UBD interacts with GNL3LProteinHetionet hetionet:interacts:10537-54552Inferred only
GNL3L participates in miR targeted genes in lymphocytesPathwayWikiPathways WP2004Inferred only
GNL3L participates in miR targeted genes in muscle cellPathwayWikiPathways WP2005Inferred only
GNL3L regulates negative regulation of protein sumoylationBiological processgene ontology Q9NVN8|GO:0033234Inferred only
GNL3L regulates negative regulation of protein ubiquitinationBiological processgene ontology Q9NVN8|GO:0031397Inferred only
GNL3L regulates negative regulation of telomere maintenance via telomeraseBiological processgene ontology Q9NVN8|GO:0032211Inferred only
GNL3L regulates positive regulation of protein localization to chromosome, telomeric regionBiological processgene ontology Q9NVN8|GO:1904816Inferred only
GNL3L regulates positive regulation of protein-containing complex assemblyBiological processgene ontology Q9NVN8|GO:0031334Inferred only
GNL3L regulates regulation of protein stabilityBiological processgene ontology Q9NVN8|GO:0031647Inferred only

Other names

1 name

Resolves to: GNL3L

Also called: Guanine nucleotide-binding protein-like 3-like protein

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