Loading the page.
Proteins/UNIPROT:Q5VU57
Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK. Mediates the deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation (By similarity). Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis..
Function from UniProtKB (Q5VU57), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
48 statements
48 statements · 3 reference databases · Subject: AGBL4 · Sources: Hetionet, Reactome, UniProt
2 reactions
(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein]+water(L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein]+L-glutamate(1-)
Catalysed by AGBL2 or AGBL4 or AGBL5 or AGTPBP1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:60004CC BY 4.0Reference data
C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin]+waterC-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin]+L-glutamate(1-)
Catalysed by
4 names
Resolves to: AGBL4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:63792CC BY 4.0Reference data