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Proteins/UNIPROT:Q9H172
ATP-dependent transporter of the ATP-binding cassette (ABC) family that may be involved in the cellular efflux of sterols, in particular cholesterol and desmosterol (a cholesterol precursor), to high-density lipoprotein (HDL). May play an important role in the removal of amyloid-beta peptides from brain, in a process that can be antagonized by desmosterol. However it is unclear whether ABCG4 can directly transport amyloid-beta peptides or whether peptide export may be facilitated due to changes in the membrane lipid environment (By similarity). Induces apoptosis in various cells..
Function from UniProtKB (Q9H172), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
43 statements
43 statements · 6 reference databases · Subject: ABCG4 · Sources: gene ontology, Hetionet, Human Protein Atlas, Reactome, Rhea, WikiPathways
2 reactions
cholesterol+ATP(4-)+watercholesterol+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCA8 or ABCA1 or ABCG1 or ABCA13 or ABCA5 or ABCA3 or ABCG4 or ABCG8 or ABCG5
Reaction pageLeft to rightBalanced
2 names
Resolves to: ABCG4
desmosterol+ATP(4-)+waterdesmosterol+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCG4
Reaction pageLeft to rightBalanced
Rhea RHEA:67932CC BY 4.0Reference data