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Proteins/UNIPROT:Q86UE4
Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance..
Function from UniProtKB (Q86UE4), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
45 statements
45 statements · 3 reference databases · Subject: MTDH · Sources: gene ontology, Hetionet, WikiPathways
8 names
Resolves to: MTDH