Pathway
ADORA2B mediated anti-inflammatory cytokines production
The natural ligand for adenosine receptor A2B (ADORA2B) is extracellular adenosine (Ad-Rib), formed from the reduction of ATP by ENTDPases. ATP enters the extracellular space in response to parasite infection, tissue injury, apoptosis amongst other stress factors and has chemotactic and excitatory effects (Cekic et al.2016).
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The reduction of ATP to Ade Rib is thought to be a regulatory mechanism by which the synthesis of anti inflammatory cytokines is induced. In addition, killing mechanisms are switched off. Accordingly, increased expression of ADORA2B in monocytes correlates with higher Leishmania donovani parasites loads alongside increment of IL10 production. Exacerbation of lesion development in L. amazonensis infected mice also correlated with high amounts of Ade Rib.
REACT:R-HSA-9660821Reactome
What the reference databases state
Statements
41 statements
41 statements · 1 reference database · Subject: ADORA2B mediated anti-inflammatory cytokines production · Sources: Reactome
- ADCY1 participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- ADCY2 participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- ADCY3 participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- ADCY4 participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- ADCY5 participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- ADCY6 participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- ADCY7 participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- ADCY8 participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- ADCY9 participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- ADORA2B participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- GNAI1 participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- GNAI2 participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
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- GNAI3 participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- GNAT3 participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- GNAZ participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- GNB1 participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- GNB2 participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- GNB3 participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- GNB4 participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- GNB5 participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- GNG10 participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- GNG11 participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- GNG12 participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- GNG13 participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- GNG2 participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- GNG3 participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- GNG4 participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- GNG5 participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- GNG7 participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- GNG8 participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- GNGT1 participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- GNGT2 participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- IL6 participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- PRKACA participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- PRKACB participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- PRKACG participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- PRKAR1A participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- PRKAR1B participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- PRKAR2A participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- PRKAR2B participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only
- PRKX participates in ADORA2B mediated anti-inflammatory cytokines productionProteinReactome R-HSA-9660821Inferred only