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Proteins/UNIPROT:P25092
Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP. Receptor for the E.coli heat-stable enterotoxin; E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C. Also activated by the endogenous peptides guanylin and uroguanylin..
Function from UniProtKB (P25092), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
14 statements
14 statements · 2 reference databases · Subject: GUCY2C · Sources: Hetionet, Reactome
2 reactions
7 names
Resolves to: GUCY2C
GTP3',5'-cyclic GMP+diphosphate(3-)
Catalysed by NPR1 or NPR2 or GUCY2C or GUCY1A2 or GUCY2F or GUCY1A1 or GUCY1B1 or GUCY2D
Reaction pageLeft to rightBalanced
Rhea RHEA:13665CC BY 4.0Reference data