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Proteins/UNIPROT:P40145
Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells..
Function from UniProtKB (P40145), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
81 statements
81 statements · 6 reference databases · Subject: ADCY8 · Sources: gene ontology, Hetionet, Reactome, Rhea, UniProt, WikiPathways
3 reactions
5 names
Resolves to: ADCY8
GTP3',5'-cyclic GMP+diphosphate(3-)
Catalysed by GUCY1A1 & GUCY1B1 or GUCY2C or ADCY2 or GUCY2F or ADCY7 or GUCY2D or ADCY3 or ADCY10 or GUCY1A2 or ADCY8 or NPR2 or NPR1
Reaction pageLeft to rightBalancedEC 4.6.1.1, 4.6.1.2cytosol
Human-GEM MAR04022CC BY 4.0Reference data
ATP(4-)3',5'-cyclic AMP+diphosphate(3-)
Catalysed by ADCY6 or ADCY3 or ADCY9 or ADCY5 or ADCY8 or ADCY7 or ADCY2 or ADCY1 or ADCY4 or ADCY10
Reaction pageDirection not assertedBalanced
Rhea RHEA:15389CC BY 4.0Reference data