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Proteins/UNIPROT:P33402
Alpha subunit of soluble guanylate cyclase (sGC), a central enzyme in nitric oxide (NO) signaling. Functions as the main intracellular receptor for NO. Upon NO binding, catalyzes the conversion of GTP to cyclic GMP (cGMP) and thereby transducing NO signal into a ubiquitous intracellular second messenger..
[Isoform 2]: Acts as a negative regulator of guanylyl cyclase activity as it forms non-functional heterodimers with the beta subunit..
Function from UniProtKB (P33402), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
19 statements
19 statements · 4 reference databases · Subject: GUCY1A2 · Sources: Hetionet, Reactome, UniProt, WikiPathways
2 reactions
3 names
Resolves to: GUCY1A2
GTP3',5'-cyclic GMP+diphosphate(3-)
Catalysed by NPR1 or NPR2 or GUCY2C or GUCY1A2 or GUCY2F or GUCY1A1 or GUCY1B1 or GUCY2D
Reaction pageLeft to rightBalanced
Rhea RHEA:13665CC BY 4.0Reference data