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Proteins/UNIPROT:Q02108
Alpha subunit of soluble guanylate cyclase (sGC), a key enzyme in nitric oxide (NO) signaling. sGC functions as a heterodimer consisting of one alpha and one beta subunit. It serves as the primary intracellular receptor for NO, which binds to a heme prosthetic group located on the beta subunit. Upon NO binding, sGC catalyzes the conversion of GTP into cyclic GMP (cGMP), thereby transmitting the NO signal into an ubiquitous intracellular second messenger..
Function from UniProtKB (Q02108), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
21 statements
21 statements · 4 reference databases · Subject: GUCY1A1 · Sources: Hetionet, Reactome, UniProt, WikiPathways
3 reactions
7 names
Resolves to: GUCY1A1
GTP3',5'-cyclic GMP+diphosphate(3-)
Catalysed by GUCY1A1 & GUCY1B1 or GUCY2C or ADCY2 or GUCY2F or ADCY7 or GUCY2D or ADCY3 or ADCY10 or GUCY1A2 or ADCY8 or NPR2 or NPR1
Reaction pageLeft to rightBalancedEC 4.6.1.1, 4.6.1.2cytosol
Human-GEM MAR04022CC BY 4.0Reference data
GTP3',5'-cyclic GMP+diphosphate(3-)
Catalysed by NPR1 or NPR2 or GUCY2C or GUCY1A2 or GUCY2F or GUCY1A1 or GUCY1B1 or GUCY2D
Reaction pageLeft to rightBalanced
Rhea RHEA:13665CC BY 4.0Reference data