Proteins/UNIPROT:Q49B96

COX19

ProteinUNIPROT:Q49B96

Assembly factor for cytochrome c oxidase (respiratory chain complex IV, CIV). Acts as a COX11 chaperone that supports COX11 copper coordination. Also stimulates SCO2-mediated metalation of COX2. Required for the transduction of an SCO1-dependent redox signal from the mitochondrion to ATP7A to regulate cellular copper homeostasis. In the absence of COX11, capable of stimulating copper delivery to the copper B site of COX1..

Function from UniProtKB (Q49B96), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

20 statements

20 statements · 3 reference databases · Subject: COX19 · Sources: Hetionet, Reactome, WikiPathways

Order

COX19 covaries with ABHD3ProteinHetionet hetionet:covaries:171586-90639Inferred only
COX19 covaries with DLX2ProteinHetionet hetionet:covaries:1746-90639Inferred only
COX19 covaries with FKBP2ProteinHetionet hetionet:covaries:2286-90639Inferred only
COX19 covaries with HMCN1ProteinHetionet hetionet:covaries:83872-90639Inferred only
COX19 covaries with IHHProteinHetionet hetionet:covaries:3549-90639Inferred only
COX19 covaries with INPP5FProteinHetionet hetionet:covaries:22876-90639Inferred only
MSRB1 covaries with COX19ProteinHetionet hetionet:covaries:51734-90639Inferred only
PALS2 covaries with COX19ProteinHetionet hetionet:covaries:51678-90639Inferred only
COX19 covaries with PUM2ProteinHetionet hetionet:covaries:23369-90639Inferred only
COX19 covaries with RAB17ProteinHetionet hetionet:covaries:64284-90639Inferred only
SMURF1 covaries with COX19ProteinHetionet hetionet:covaries:57154-90639Inferred only
COX19 covaries with TMOD2ProteinHetionet hetionet:covaries:29767-90639Inferred only

Show the remaining 8

COX19 covaries with TRIP11ProteinHetionet hetionet:covaries:90639-9321Inferred only
COX19 participates in Aerobic respiration and respiratory electron transportPathwayReactome R-HSA-1428517Inferred only
COX19 participates in Complex IV assemblyPathwayReactome R-HSA-9864848Inferred only
COX19 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
COX19 participates in Mitochondrial complex IV assemblyPathwayWikiPathways WP4922Inferred only
COX19 participates in Mitochondrial protein importPathwayReactome R-HSA-1268020Inferred only
COX19 participates in Protein localizationPathwayReactome R-HSA-9609507Inferred only
COX19 participates in Respiratory electron transportPathwayReactome R-HSA-611105Inferred only

Other names

2 names

Resolves to: COX19

Also called: Cytochrome c oxidase assembly protein COX19hCOX19

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