(2E)-tetracosenoyl-CoA

Three steps

• decanoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by TECRL, TECR, BAAT, THEM4 and 6 morecytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by TECRL, TECR, BAAT, THEM4 and 3 morecytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by TECRL, TECR, BAAT, THEM4 and 8 morecytosolOne of 12 routes

• a cardiolipinReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA = a cardiolipin + CoA

  Catalysed by TECRL, TECR, HADHAcytosol

• 3-hydroxyisovaleryl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by TECRL, TECR, BAAT, THEM4 and 2 morecytosol

• an all-trans-retinyl esterReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA

  Catalysed by TECRL, TECR, DGAT1, PNPLA4 and 2 morecytosol

• CHEBI:63544Reach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by TECRL, TECR, BAAT, THEM4 and 8 morecytosolOne of 8 routes

• a 1,2-diacyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by TECRL, TECR, LPCAT4, LPCAT3 and 2 morecytosol

• a triacyl-sn-glycerolReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA

  Catalysed by TECRL, TECR, DGAT1, MOGAT2 and 4 morecytosol

• a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by TECRL, TECR, LCLAT1, LPCAT1 and 1 morecytosol

• hexacosanoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by TECRL, TECR, BAAT, THEM4 and 8 morecytosolOne of 6 routes

• N-docosanoylsphinganineReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Fatty Acid Beta Oxidation (C24->C22), Peroxisomal
  3. docosanoyl-CoA + sphinganine = N-docosanoylsphinganine + CoA + H(+)

  Catalysed by TECRL, TECR, ACAA1, HSD17B4 and 5 morecytosol, peroxisome

• N-eicosanoylsphinganineReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. eicosanoyl-CoA + sphinganine = N-eicosanoylsphinganine + CoA + H(+)

  Catalysed by TECRL, TECR, ACAA1, HSD17B4 and 5 morecytosol, peroxisome

• (2E)-octadecenoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by TECRL, TECR, BAAT, THEM4 and 3 morecytosolOne of 3 routes

• 3-oxodocosanoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. very-long-chain 3-oxoacyl-CoA synthase (eicosanoyl-CoA)

  Catalysed by TECRL, TECR, ACAA1, HSD17B4 and 9 morecytosol, peroxisomeOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by TECRL, TECR, BAAT, THEM4 and 8 morecytosolOne of 9 routes

• N-eicosanoyl-sphing-4-enineReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. eicosanoyl-CoA + sphing-4-enine = N-eicosanoyl-sphing-4-enine + CoA + H(+)

  Catalysed by TECRL, TECR, ACAA1, HSD17B4 and 4 morecytosol, peroxisome

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by TECRL, TECR, BAAT, THEM4 and 8 morecytosolOne of 10 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by TECRL, TECR, BAAT, THEM4 and 8 morecytosolOne of 7 routes

• 3-oxotetracosanoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Fatty Acid Beta Oxidation (C24->C22), Peroxisomal
  3. very-long-chain 3-oxoacyl-CoA synthase (docosanoyl-CoA)

  Catalysed by TECRL, TECR, ACAA1, HSD17B4 and 9 morecytosol, peroxisomeOne of 3 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by TECRL, TECR, BAAT, THEM4 and 8 morecytosolOne of 8 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by TECRL, TECR, BAAT, THEM4 and 8 morecytosolOne of 7 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by TECRL, TECR, BAAT, THEM4 and 8 morecytosolOne of 8 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by TECRL, TECR, BAAT, THEM4 and 8 morecytosolOne of 6 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by TECRL, TECR, BAAT, THEM4 and 8 morecytosolOne of 5 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by TECRL, TECR, BAAT, THEM4 and 8 morecytosolOne of 8 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by TECRL, TECR, BAAT, THEM4 and 8 morecytosolOne of 5 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by TECRL, TECR, BAAT, THEM4 and 8 morecytosolOne of 6 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by TECRL, TECR, BAAT, THEM4 and 8 morecytosolOne of 6 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by TECRL, TECR, BAAT, THEM4 and 8 morecytosolOne of 8 routes

• heptadecanoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (margaric acid)

  Catalysed by TECRL, TECR, BAAT, THEM4 and 8 morecytosolOne of 7 routes

• (9Z)-heptadecenoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)

  Catalysed by TECRL, TECR, BAAT, THEM4 and 8 morecytosolOne of 6 routes

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

  Catalysed by TECRL, TECR, BAAT, THEM4 and 8 morecytosolOne of 6 routes

• (2E)-eicosenoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. acyl-CoA oxidase (eicosanoyl-CoA)

  Catalysed by TECRL, TECR, ACAA1, HSD17B4 and 3 morecytosol, peroxisomeOne of 4 routes

• (2E)-docosenoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Fatty Acid Beta Oxidation (C24->C22), Peroxisomal
  3. acyl-CoA oxidase (docosanoyl-CoA)

  Catalysed by TECRL, TECR, ACAA1, HSD17B4 and 3 morecytosol, peroxisomeOne of 4 routes

• 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphateReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. eicosanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by TECRL, TECR, ACAA1, HSD17B4 and 3 morecytosol, peroxisome

• nonadecanoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (nonadecylic acid)

  Catalysed by TECRL, TECR, BAAT, THEM4 and 8 morecytosolOne of 7 routes

• (11Z)-octadecenoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix

  Catalysed by TECRL, TECR, BAAT, THEM4 and 3 morecytosolOne of 3 routes

• a 2,3-diacyl-sn-glycerolReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. a 2-acylglycerol + an acyl-CoA = a 2,3-diacyl-sn-glycerol + CoA

  Catalysed by TECRL, TECR, MOGAT2, MOGAT1cytosol

• eicosan-1-olReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. eicosanoyl-CoA + 2 NADPH + 2 H(+) = eicosan-1-ol + 2 NADP(+) + CoA

  Catalysed by TECRL, TECR, ACAA1, HSD17B4 and 4 morecytosol, peroxisome

• (R)-2-hydroxytetracosanoateReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. tetracosanoate + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (R)-2-hydroxytetracosanoate + 2 Fe(III)-[cytochrome b5] + H2O

  Catalysed by TECRL, TECR, BAAT, THEM4 and 1 morecytosol

• 1-O-alkyl-3-acylglycerolReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. 1-O-alkylglycerol + an acyl-CoA = 1-O-alkyl-3-acylglycerol + CoA

  Catalysed by TECRL, TECR, MOGAT2, AWAT2cytosol

• dodecanedioyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Activation of dodecanedioic acid

  Catalysed by TECRL, TECR, BAAT, THEM4cytosolOne of 4 routes

• decanedioyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Production of Sebacoylcarnitine

  Catalysed by TECRL, TECR, BAAT, THEM4 and 3 morecytosolOne of 4 routes

• octanedioyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Production of Suberylcarnitine

  Catalysed by TECRL, TECR, BAAT, THEM4 and 3 morecytosolOne of 4 routes

• hexanedioyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Activation of adipic acid for Formation of Adipoyl Carnitine

  Catalysed by TECRL, TECR, BAAT, THEM4cytosolOne of 4 routes

• (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)

  Catalysed by TECRL, TECR, BAAT, THEM4 and 8 morecytosolOne of 8 routes

• (11Z,14Z)-eicosadienoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)

  Catalysed by TECRL, TECR, BAAT, THEM4 and 8 morecytosolOne of 6 routes

• (R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Production of 3-Hydroxyoctadecenoylcarnitinec

  Catalysed by TECRL, TECR, BAAT, THEM4 and 3 morecytosol

• (13Z)-eicosenoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase ((2E)-tetracosenoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

  Catalysed by TECRL, TECR, BAAT, THEM4 and 8 morecytosolOne of 6 routes