(8Z,11Z,14Z)-eicosatrienoyl-CoA

1. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
2. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

Catalysed by FADS1, MBOAT7, AGPAT3

1. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
2. 1-O-octadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-O-octadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA

Catalysed by FADS1, LPCAT2

1. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
2. 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

Catalysed by FADS1, LPCAT4

1. acyl-CoA pool formation and breakdown
2. a 2-acylglycerol + an acyl-CoA = a 2,3-diacyl-sn-glycerol + CoA

Catalysed by MOGAT2, MOGAT1cytosol

1. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
2. 2-(9Z-octadecenoyl)-glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA

Catalysed by FADS1, MOGAT2, MOGAT1

1. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
2. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho]-glycerol + CoA

Catalysed by FADS1, LCLAT1

1. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
2. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA

Catalysed by FADS1, LCLAT1

1. acyl-CoA pool formation and breakdown
2. 1-O-alkylglycerol + an acyl-CoA = 1-O-alkyl-3-acylglycerol + CoA

Catalysed by MOGAT2, AWAT2cytosol

1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. Activation of dodecanedioic acid

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosolOne of 4 routes

1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. Production of Sebacoylcarnitine

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosolOne of 4 routes

1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. Production of Suberylcarnitine

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosolOne of 4 routes

1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. Activation of adipic acid for Formation of Adipoyl Carnitine

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosolOne of 4 routes

1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 8 routes

1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 6 routes

1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. Production of 3-Hydroxyoctadecenoylcarnitinec

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol

1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 6 routes

1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosol, peroxisomeOne of 3 routes

1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 5 morecytosol, peroxisome

1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. Production of Hexadecanedioylcarnitine

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosolOne of 2 routes

1. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
2. 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA

Catalysed by FADS1, AGPAT3

1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. fatty-acid-CoA ligase

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosolOne of 2 routes

1. acyl-CoA pool formation and breakdown
2. a 3-acyl-sn-glycerol + an acyl-CoA = a 1,3-diacyl-sn-glycerol + CoA

Catalysed by MOGAT1cytosolOne of 2 routes

1. acyl-CoA pool formation and breakdown
2. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA

Catalysed by LPCAT2, LPCAT1cytosol

1. acyl-CoA pool formation and breakdown
2. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA

Catalysed by LPCAT4cytosol

1. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
2. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA

Catalysed by FADS1, LPCAT4, LPCAT3

1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. medium-chain acyl-CoA ligase (undecylic acid)

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 7 morecytosolOne of 3 routes

1. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
2. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoA

Catalysed by FADS1, AGPAT3, AGPAT5

1. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
2. 1-heptadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA

Catalysed by FADS1, AGPAT3

1. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA

Catalysed by FADS1, SOAT2, SOAT1

1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (physeteric acid)

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 9 routes

1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 5 morecytosol, mitochondrial matrix

1. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
2. 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-O-(9Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA

Catalysed by FADS1, AGPAT3

1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrix

1. acyl-CoA pool formation and breakdown
2. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

Catalysed by GLYATL1B, GLYATL1cytosol

1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 9 routes

1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 5 routes

1. acyl-CoA pool formation and breakdown
2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA

Catalysed by ACAA1, SCP2, ACAA2, HADHBcytosol

1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. glycine N-acyltransferase (N-arachidonoylglycine)
3. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine

Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 5 morecytosol, mitochondrial matrixOne of 2 routes

1. Acyl-CoA:cholesterol O-acyltransferase
2. Steryl-ester acylhydrolase
3. cytochrome P450 (cholesterol)