(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA

1. fatty-acyl-CoA elongation (N-C20:5CoA)
2. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA hydrolase

Catalysed by ELOVL4, ELOVL6, ELOVL2, ELOVL5 and 2 morecytosol

1. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA hydrolase
2. fatty-acid-CoA ligase

Catalysed by BAAT, ACOT6, ACOT1, SLC27A2cytosolOne of 2 routes

1. acyl-CoA pool formation and breakdown
2. a 3-acyl-sn-glycerol + an acyl-CoA = a 1,3-diacyl-sn-glycerol + CoA

Catalysed by MOGAT1cytosolOne of 2 routes

1. acyl-CoA pool formation and breakdown
2. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA

Catalysed by LPCAT2, LPCAT1cytosol

1. acyl-CoA pool formation and breakdown
2. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA

Catalysed by LPCAT4cytosol

1. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA hydrolase
2. medium-chain acyl-CoA ligase (undecylic acid)

Catalysed by BAAT, ACOT6, ACOT1, ACSM4 and 5 morecytosolOne of 3 routes

1. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA hydrolase
2. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = (5Z,7Z,8Z,10E,14Z,17Z)-12-hydroperoxyeicosapentaenoate

Catalysed by BAAT, ACOT6, ACOT1, ALOX12Bcytosol

1. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (physeteric acid)

Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 7 morecytosolOne of 9 routes

1. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA hydrolase
2. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

Catalysed by BAAT, ACOT6, ACOT1, ACADM and 3 morecytosol, mitochondrial matrix

1. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA hydrolase
2. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

Catalysed by BAAT, ACOT6, ACOT1, HADHA and 2 morecytosol, mitochondrial matrix

1. acyl-CoA pool formation and breakdown
2. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

Catalysed by GLYATL1B, GLYATL1cytosol

1. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 7 morecytosolOne of 9 routes

1. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 7 morecytosolOne of 5 routes

1. acyl-CoA pool formation and breakdown
2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA

Catalysed by ACAA1, SCP2, ACAA2, HADHBcytosol

1. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA hydrolase
2. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate

Catalysed by BAAT, ACOT6, ACOT1, ALOX12cytosol

1. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA hydrolase
2. prostaglandin-endoperoxide synthase (EPA)

Catalysed by BAAT, ACOT6, ACOT1, PTGS1 and 1 morecytosolOne of 2 routes

1. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA hydrolase
2. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O

Catalysed by BAAT, ACOT6, ACOT1, PTGS2cytosol

1. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA hydrolase
2. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O

Catalysed by BAAT, ACOT6, ACOT1, PTGS2cytosol

1. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA hydrolase
2. glycine N-acyltransferase (N-arachidonoylglycine)
3. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine

Catalysed by BAAT, ACOT6, ACOT1, GLYAT and 3 morecytosol, mitochondrial matrixOne of 2 routes

1. Acyl-CoA:cholesterol O-acyltransferase
2. Steryl-ester acylhydrolase
3. cytochrome P450 (cholesterol)