L-threonylcarbamoyladenylate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

124 compounds within 3 steps: 1 in 1, 6 in 2, 117 in 3

Three steps

L-phenylalanineReach from here →
1. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O
2. L-threonine = acetaldehyde + glycine
3. transport of glycine and phenylalanine (cytosol to extracellular)
Catalysed by YRDC, SHMT1, SLC7A5extracellular space, cytosolOne of 20 routes
3-hydroxy-L-kynurenineReach from here →
1. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O
2. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)
3. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)
Catalysed by YRDC, SLC7A10, KYNUinner side of the membrane, outer side of the membrane
phosphoethanolamineReach from here →
1. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O
2. L-threonine = acetaldehyde + glycine
3. phosphoethanolamine + H2O = acetaldehyde + NH4(+) + phosphate
Catalysed by YRDC, SHMT1, ETNPPL
carbamoyl phosphateReach from here →
1. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O
2. L-threonine(in) + L-glutamine(out) + Na(+)(out) = L-threonine(out) + L-glutamine(in) + Na(+)(in)
3. HCO3-:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating)
Catalysed by YRDC, SLC1A5, CADinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes
L-tyrosineReach from here →
1. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O
2. L-threonine = acetaldehyde + glycine
3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
Catalysed by YRDC, SHMT1, AADAT
N(omega),N(omega)-dimethyl-L-arginineReach from here →
1. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O
2. L-threonine = acetaldehyde + glycine
3. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine
Catalysed by YRDC, SHMT1, AGXT2One of 2 routes
kynurenateReach from here →
1. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O
2. L-threonine = 2-oxobutanoate + NH4(+)
3. 2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + kynurenate + H2O
Catalysed by YRDC, SDS, SDSL, AADAT
5-phospho-beta-D-ribosylamineReach from here →
1. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O
2. L-threonine(in) + L-glutamine(out) + Na(+)(out) = L-threonine(out) + L-glutamine(in) + Na(+)(in)
3. phosphoribosyl pyrophosphate amidotransferase (glutamine)
Catalysed by YRDC, SLC1A5, PPATinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes
D-glucosamine 6-phosphateReach from here →
1. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O
2. L-threonine(in) + L-glutamine(out) + Na(+)(out) = L-threonine(out) + L-glutamine(in) + Na(+)(in)
3. D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate
Catalysed by YRDC, SLC1A5, GFPT2, GFPT1inner side of the membrane, outer side of the membrane
N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
1. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O
2. L-threonine = acetaldehyde + glycine
3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
Catalysed by YRDC, SHMT1, GLYATL2One of 2 routes
L-prolineReach from here →
1. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O
2. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)
3. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)
Catalysed by YRDC, SLC7A10, SLC1A4inner side of the membrane, outer side of the membraneOne of 2 routes
N-benzoylglycineReach from here →
1. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O
2. L-threonine = acetaldehyde + glycine
3. Hippurate (Benzoylglycinate) Formation
Catalysed by YRDC, SHMT1mitochondrial matrixOne of 2 routes
L-cysteinylglycineReach from here →
1. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O
2. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)
3. gamma-glutamyltransferase (alanine)
Catalysed by YRDC, SLC7A10, GGTLC3, GGT1 and 4 moreinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes
(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylateReach from here →
1. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O
2. trans-4-hydroxy-L-proline(out) + L-threonine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-threonine(out) + Na(+)(in)
3. trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)
Catalysed by YRDC, SLC1A4, PRODH2inner side of the membrane, outer side of the membrane
2-deoxy-D-ribose 5-phosphateReach from here →
1. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O
2. L-threonine = acetaldehyde + glycine
3. 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde
Catalysed by YRDC, SHMT1, DERA
Mo-molybdopterinReach from here →
1. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O
2. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)
3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
Catalysed by YRDC, SLC7A10, MOCOSinner side of the membrane, outer side of the membrane
(2S)-2-aminobutanoateReach from here →
1. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O
2. L-threonine = acetaldehyde + glycine
3. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
Catalysed by YRDC, SHMT1, AGXT2One of 7 routes
2-iminobutanoateReach from here →
1. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O
2. L-threonine = 2-oxobutanoate + NH4(+)
3. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
Catalysed by YRDC, SDS, SDSL, RIDA
glycodeoxycholateReach from here →
1. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O
2. L-threonine = acetaldehyde + glycine
3. Glycodeoxycholate amidohydrolase
Catalysed by YRDC, SHMT1cytosolOne of 2 routes
N-tetradecanoylglycineReach from here →
1. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O
2. L-threonine = acetaldehyde + glycine
3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
Catalysed by YRDC, SHMT1, GLYATL2
N-eicosanoylglycinateReach from here →
1. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O
2. L-threonine = acetaldehyde + glycine
3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)
Catalysed by YRDC, SHMT1, BAAT
N-docosanoylglycineReach from here →
1. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O
2. L-threonine = acetaldehyde + glycine
3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)
Catalysed by YRDC, SHMT1, BAAT
N-hexacosanoylglycineReach from here →
1. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O
2. L-threonine = acetaldehyde + glycine
3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)
Catalysed by YRDC, SHMT1, BAAT
an N(2)-acyl-L-glutamineReach from here →
1. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O
2. L-threonine(in) + L-glutamine(out) + Na(+)(out) = L-threonine(out) + L-glutamine(in) + Na(+)(in)
3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
Catalysed by YRDC, SLC1A5, GLYATL1B, GLYATL1inner side of the membrane, outer side of the membrane