xanthurenate

Three steps

• gamma-Glu-AlaReach from here →
  1. Kynurenine-Oxoglutarate Transaminase
  2. 3-Hydroxy-L-kynurenine hydrolase
  3. gamma-glutamyltransferase (alanine)

  Catalysed by AADAT, KYNU, GGT1, GGT5 and 4 moremitochondrial matrix, cytosol, extracellular space

• glycineReach from here →
  1. Kynurenine-Oxoglutarate Transaminase
  2. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
  3. L-kynurenine + glyoxylate = kynurenate + glycine + H2O

  Catalysed by AADAT, KMO, KYAT3mitochondrial matrix, cytosolOne of 15 routes

• D-alanineReach from here →
  1. Kynurenine-Oxoglutarate Transaminase
  2. 3-Hydroxy-L-kynurenine hydrolase
  3. D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)

  Catalysed by AADAT, KYNU, SLC7A10mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-threonineReach from here →
  1. Kynurenine-Oxoglutarate Transaminase
  2. 3-Hydroxy-L-kynurenine hydrolase
  3. D-threonine(out) + L-alanine(in) = D-threonine(in) + L-alanine(out)

  Catalysed by AADAT, KYNU, SLC7A10mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-methionineReach from here →
  1. Kynurenine-Oxoglutarate Transaminase
  2. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
  3. 4-methylsulfanyl-2-oxobutanoate + L-kynurenine = kynurenate + L-methionine + H2O

  Catalysed by AADAT, KMOmitochondrial matrix, cytosolOne of 12 routes

• L-threonineReach from here →
  1. Kynurenine-Oxoglutarate Transaminase
  2. 3-Hydroxy-L-kynurenine hydrolase
  3. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)

  Catalysed by AADAT, KYNU, SLC7A10mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• beta-alanineReach from here →
  1. Kynurenine-Oxoglutarate Transaminase
  2. 3-Hydroxy-L-kynurenine hydrolase
  3. beta-alanine(out) + L-alanine(in) = beta-alanine(in) + L-alanine(out)

  Catalysed by AADAT, KYNU, SLC7A10mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-asparagineReach from here →
  1. Kynurenine-Oxoglutarate Transaminase
  2. 3-Hydroxy-L-kynurenine hydrolase
  3. transport of alanine and asparagine (cytosol to extracellular)

  Catalysed by AADAT, KYNU, SLC7A5mitochondrial matrix, cytosol, extracellular spaceOne of 9 routes

• L-phenylalanineReach from here →
  1. Kynurenine-Oxoglutarate Transaminase
  2. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
  3. Transport of L-Kynurenine

  Catalysed by AADAT, KMO, SLC7A8mitochondrial matrix, cytosol, extracellular spaceOne of 15 routes

• 3-hydroxy-L-kynurenineReach from here →
  1. Kynurenine-Oxoglutarate Transaminase
  2. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
  3. L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O

  Catalysed by AADAT, KMOmitochondrial matrix, cytosolOne of 2 routes

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. Kynurenine-Oxoglutarate Transaminase
  2. 3-Hydroxy-L-kynurenine hydrolase
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by AADAT, KYNU, AGXT2mitochondrial matrix, cytosol

• trans-4-hydroxy-L-prolineReach from here →
  1. Kynurenine-Oxoglutarate Transaminase
  2. 3-Hydroxy-L-kynurenine hydrolase
  3. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by AADAT, KYNU, SLC1A4mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-2-aminopentanoateReach from here →
  1. Kynurenine-Oxoglutarate Transaminase
  2. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
  3. 2-oxopentanoate + L-kynurenine = L-2-aminopentanoate + kynurenate + H2O

  Catalysed by AADAT, KMOmitochondrial matrix, cytosol

• kynurenateReach from here →
  1. Kynurenine-Oxoglutarate Transaminase
  2. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
  3. Kynurenine-Oxoglutarate Transaminase

  Catalysed by AADAT, KMO, KYAT3mitochondrial matrix, cytosolOne of 13 routes

• L-2-aminohexanoateReach from here →
  1. Kynurenine-Oxoglutarate Transaminase
  2. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
  3. 2-oxohexanoate + L-kynurenine = L-2-aminohexanoate + kynurenate + H2O

  Catalysed by AADAT, KMOmitochondrial matrix, cytosol

• N-formyl-L-kynurenineReach from here →
  1. Kynurenine-Oxoglutarate Transaminase
  2. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
  3. N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)

  Catalysed by AADAT, KMO, AFMIDmitochondrial matrix, cytosolOne of 2 routes

• L-2-aminoadipateReach from here →
  1. Kynurenine-Oxoglutarate Transaminase
  2. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
  3. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O

  Catalysed by AADAT, KMOmitochondrial matrix, cytosol

• an L-alpha-amino acidReach from here →
  1. Kynurenine-Oxoglutarate Transaminase
  2. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
  3. an L-alpha-amino acid(in) + L-kynurenine(out) = an L-alpha-amino acid(out) + L-kynurenine(in)

  Catalysed by AADAT, KMO, SLC7A11mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-prolineReach from here →
  1. Kynurenine-Oxoglutarate Transaminase
  2. 3-Hydroxy-L-kynurenine hydrolase
  3. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by AADAT, KYNU, SLC1A4mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-cysteinylglycineReach from here →
  1. Kynurenine-Oxoglutarate Transaminase
  2. 3-Hydroxy-L-kynurenine hydrolase
  3. gamma-glutamyltransferase (alanine)

  Catalysed by AADAT, KYNU, GGTLC3, GGT1 and 4 moremitochondrial matrix, cytosolOne of 2 routes

• Mo-molybdopterinReach from here →
  1. Kynurenine-Oxoglutarate Transaminase
  2. 3-Hydroxy-L-kynurenine hydrolase
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by AADAT, KYNU, MOCOSmitochondrial matrix, cytosol

• (2S)-2-aminobutanoateReach from here →
  1. Kynurenine-Oxoglutarate Transaminase
  2. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
  3. 2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + kynurenate + H2O

  Catalysed by AADAT, KMOmitochondrial matrix, cytosolOne of 2 routes

• (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehydeReach from here →
  1. Kynurenine-Oxoglutarate Transaminase
  2. 3-Hydroxy-L-kynurenine hydrolase
  3. 3-Hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing)

  Catalysed by AADAT, KYNU, HAAOmitochondrial matrix, cytosol