leukotriene D4

Three steps

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

  Catalysed by DPEP1, DPEP2, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 5 routes

• nonadecanoyl-CoAReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (nonadecylic acid)

  Catalysed by DPEP1, DPEP2, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 6 routes

• (11Z)-octadecenoyl-CoAReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix

  Catalysed by DPEP1, DPEP2, BAAT, CPT1A and 2 moreperoxisome, cytosolOne of 3 routes

• dodecanedioyl-CoAReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Activation of dodecanedioic acid

  Catalysed by DPEP1, DPEP2, BAATperoxisome, cytosolOne of 4 routes

• decanedioyl-CoAReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Production of Sebacoylcarnitine

  Catalysed by DPEP1, DPEP2, BAAT, CPT1A and 2 moreperoxisome, cytosolOne of 4 routes

• octanedioyl-CoAReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Production of Suberylcarnitine

  Catalysed by DPEP1, DPEP2, BAAT, CPT1A and 2 moreperoxisome, cytosolOne of 4 routes

• hexanedioyl-CoAReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Activation of adipic acid for Formation of Adipoyl Carnitine

  Catalysed by DPEP1, DPEP2, BAATperoxisome, cytosolOne of 4 routes

• (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)

  Catalysed by DPEP1, DPEP2, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 7 routes

• (11Z,14Z)-eicosadienoyl-CoAReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)

  Catalysed by DPEP1, DPEP2, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 5 routes

• (R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Production of 3-Hydroxyoctadecenoylcarnitinec

  Catalysed by DPEP1, DPEP2, BAAT, CPT1A and 2 moreperoxisome, cytosol

• (13Z)-eicosenoyl-CoAReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

  Catalysed by DPEP1, DPEP2, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 5 routes

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2

  Catalysed by DPEP1, DPEP2, GSS, SLCO2A1cytosol, extracellular spaceOne of 2 routes

• 4,8-dimethylnonanoyl-CoAReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by DPEP1, DPEP2, BAAT, CRAT and 1 moreperoxisomeOne of 3 routes

• tetradecanedioyl-CoAReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal

  Catalysed by DPEP1, DPEP2, BAAT, ACAA1 and 3 moreperoxisome

• hexadecanedioyl-CoAReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Production of Hexadecanedioylcarnitine

  Catalysed by DPEP1, DPEP2, BAAT, CPT1A and 2 moreperoxisome, cytosolOne of 2 routes

• pristanoyl-CoAReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. fatty-acid-CoA ligase

  Catalysed by DPEP1, DPEP2, BAAT, SLC27A2peroxisome, cytosolOne of 2 routes

• undecanoyl-CoAReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. medium-chain acyl-CoA ligase (undecylic acid)

  Catalysed by DPEP1, DPEP2, BAAT, ACSM4 and 5 moreperoxisome, cytosolOne of 3 routes

• a fatty acyl-CoAReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by DPEP1, DPEP2, GLYATL2

• (9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by DPEP1, DPEP2, GSS, GPX1 and 1 more

• ursodeoxycholateReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and ursodeoxycholate (cytosol to extracellular)

  Catalysed by DPEP1, DPEP2, GSS, SLCO1A2 and 1 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin G2Reach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and prostaglandin G2 (cytosol to extracellular)

  Catalysed by DPEP1, DPEP2, GSS, SLCO2A1cytosol, extracellular spaceOne of 2 routes

• thio-Mo-molybdopterinReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by DPEP1, DPEP2, SLC3A2, SLC7A5 and 2 moreextracellular space, cytosol

• (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by DPEP1, DPEP2, GSS, GPX1 and 2 more

• (5Z)-tetradecenoyl-CoAReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (physeteric acid)

  Catalysed by DPEP1, DPEP2, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 8 routes

• (3E)-decenoyl-CoAReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

  Catalysed by DPEP1, DPEP2, BAAT, ACADM and 3 moreperoxisome, mitochondrial matrix

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by DPEP1, DPEP2, BAAT, HADHA and 2 moreperoxisome, mitochondrial matrix

• an N(2)-acyl-L-glutamineReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by DPEP1, DPEP2, SLC7A5, GLYATL1B and 1 moreextracellular space, cytosol

• (7Z)-hexadecenoyl-CoAReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by DPEP1, DPEP2, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 8 routes

• 3-methylmalateReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)

  Catalysed by DPEP1, DPEP2, AADAT, CLYBL

• tricosanoyl-CoAReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by DPEP1, DPEP2, BAAT, SLC27A2 and 7 moreperoxisome, cytosolOne of 4 routes

• (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by DPEP1, DPEP2, GSS, PTGES and 5 more

• (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by DPEP1, DPEP2, GSS, GPX1 and 1 more

• thromboxane B2Reach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and thromboxane B2 (cytosol to extracellular)

  Catalysed by DPEP1, DPEP2, GSS, SLCO1B1cytosol, extracellular spaceOne of 2 routes

• an S-substituted glutathioneReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by DPEP1, DPEP2, GSS, GSTT4 and 22 moreOne of 2 routes

• (13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by DPEP1, DPEP2, GSS, GPX1 and 3 more

• taurochenodeoxycholateReach from here →
  1. leukotriene D4 + H2O = leukotriene E4 + glycine
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. solute carrier organic anion transporter (GSH)

  Catalysed by DPEP1, DPEP2, GSS, SLCO1A2 and 2 morecytosol, extracellular spaceOne of 3 routes