3-oxotetradecanoyl-CoA

Three steps

• (11Z)-eicosenoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 10 moreperoxisome, cytosolOne of 8 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 10 moreperoxisome, cytosolOne of 6 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 10 moreperoxisome, cytosolOne of 5 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 10 moreperoxisome, cytosolOne of 7 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 10 moreperoxisome, cytosolOne of 5 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 10 moreperoxisome, cytosolOne of 6 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 10 moreperoxisome, cytosolOne of 6 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 10 moreperoxisome, cytosolOne of 8 routes

• heptadecanoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (margaric acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 10 moreperoxisome, cytosolOne of 7 routes

• (9Z)-heptadecenoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 10 moreperoxisome, cytosolOne of 6 routes

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 10 moreperoxisome, cytosolOne of 6 routes

• 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphateReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. fatty-acyl-CoA synthase (N-C14:0CoA)
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by ACAA1, MYO5B, AGPAT2, GPAT3 and 3 moreperoxisome, cytosol

• nonadecanoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (nonadecylic acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 10 moreperoxisome, cytosolOne of 7 routes

• (11Z)-octadecenoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 5 moreperoxisome, cytosolOne of 3 routes

• 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholineReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Fatty Acid Beta Oxidation (C12->C10), Mitochondrial
  3. decanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACAA1, MYO5B, ACADM, ECHS1 and 3 moreperoxisome, mitochondrial matrix

• 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. fatty-acyl-CoA synthase (N-C14:0CoA)
  3. tetradecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACAA1, MYO5B, LPCAT1peroxisome, cytosol

• a 2,3-diacyl-sn-glycerolReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. acyl-CoA pool formation and breakdown
  3. a 2-acylglycerol + an acyl-CoA = a 2,3-diacyl-sn-glycerol + CoA

  Catalysed by ACAA1, MYO5B, MOGAT2, MOGAT1peroxisome, cytosol

• 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. fatty-acyl-CoA synthase (N-C14:0CoA)
  3. 2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA = 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by ACAA1, MYO5B, MOGAT2, MOGAT1peroxisome, cytosol

• 1-O-alkyl-3-acylglycerolReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. acyl-CoA pool formation and breakdown
  3. 1-O-alkylglycerol + an acyl-CoA = 1-O-alkyl-3-acylglycerol + CoA

  Catalysed by ACAA1, MYO5B, MOGAT2, AWAT2peroxisome, cytosol

• dodecanedioyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. Activation of dodecanedioic acid

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 2 moreperoxisome, cytosolOne of 4 routes

• decanedioyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. Production of Sebacoylcarnitine

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 5 moreperoxisome, cytosolOne of 4 routes

• octanedioyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. Production of Suberylcarnitine

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 5 moreperoxisome, cytosolOne of 4 routes

• hexanedioyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. Activation of adipic acid for Formation of Adipoyl Carnitine

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 2 moreperoxisome, cytosolOne of 4 routes

• (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 10 moreperoxisome, cytosolOne of 8 routes

• (11Z,14Z)-eicosadienoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 10 moreperoxisome, cytosolOne of 6 routes

• (R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. Production of 3-Hydroxyoctadecenoylcarnitinec

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 5 moreperoxisome, cytosol

• (13Z)-eicosenoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 10 moreperoxisome, cytosolOne of 6 routes

• 11-hydroxydodecanoateReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. lauric acid[r] + O2[r] + FMNH2[r] = FMN[r] + H2O[r] + 11-hydroxydodecanoate[r]

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 3 moreperoxisome, cytosol, endoplasmic reticulumOne of 3 routes

• 4,8-dimethylnonanoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 4 moreperoxisome, cytosolOne of 3 routes

• tetradecanedioyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 5 moreperoxisome, cytosol

• hexadecanedioyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. Production of Hexadecanedioylcarnitine

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 5 moreperoxisome, cytosolOne of 2 routes

• pristanoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. fatty-acid-CoA ligase

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 3 moreperoxisome, cytosolOne of 2 routes

• a 1,3-diacyl-sn-glycerolReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. acyl-CoA pool formation and breakdown
  3. a 3-acyl-sn-glycerol + an acyl-CoA = a 1,3-diacyl-sn-glycerol + CoA

  Catalysed by ACAA1, MYO5B, MOGAT1peroxisome, cytosolOne of 2 routes

• a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. acyl-CoA pool formation and breakdown
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACAA1, MYO5B, LPCAT2, LPCAT1peroxisome, cytosol

• a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. acyl-CoA pool formation and breakdown
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by ACAA1, MYO5B, LPCAT4peroxisome, cytosol

• undecanoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. medium-chain acyl-CoA ligase (undecylic acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 8 moreperoxisome, cytosolOne of 3 routes

• N-dodecanoyl-(4R)-hydroxysphinganineReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. N-dodecanoyl-(4R)-hydroxysphinganine + H2O = (4R)-hydroxysphinganine + dodecanoate

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 3 moreperoxisome, cytosol

• O-tetradecanoyl-(R)-carnitineReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. fatty-acyl-CoA synthase (N-C14:0CoA)
  3. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA

  Catalysed by ACAA1, MYO5B, CPT2peroxisome, cytosol

• (5Z)-tetradecenoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (physeteric acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 10 moreperoxisome, cytosolOne of 10 routes

• (3E)-decenoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 6 moreperoxisome, cytosol, mitochondrial matrix

• 7-hydroxydodecanoateReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. dodecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 7-hydroxydodecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 3 moreperoxisome, cytosol

• N-(dodecanoyl)-sphinganineReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. N-(dodecanoyl)-sphinganine + H2O = dodecanoate + sphinganine

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 3 moreperoxisome, cytosol

• N-tetradecanoylglycineReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. fatty-acyl-CoA synthase (N-C14:0CoA)
  3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

  Catalysed by ACAA1, MYO5B, GLYATL2peroxisome, cytosol

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 5 moreperoxisome, cytosol, mitochondrial matrix

• an N(2)-acyl-L-glutamineReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. acyl-CoA pool formation and breakdown
  3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by ACAA1, MYO5B, GLYATL1B, GLYATL1peroxisome, cytosol

• (7Z)-hexadecenoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 10 moreperoxisome, cytosolOne of 9 routes

• tricosanoyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by ACAA1, MYO5B, ACOT7, BAAT and 10 moreperoxisome, cytosolOne of 5 routes

• a 3-oxoacyl-CoAReach from here →
  1. Lauroyl-CoA:acetyl-CoA C-acyltransferase
  2. acyl-CoA pool formation and breakdown
  3. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA

  Catalysed by ACAA1, MYO5B, SCP2, ACAA2 and 1 moreperoxisome, cytosol