an acyl-CoA

Two steps

• 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + (9Z,12Z)-octadecadienoyl-CoA = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA

  Catalysed by AGPAT2, GPAT3, LPCAT2, AGPAT1 and 2 morecytosol

• 1-octadecanoyl-sn-glycero-3-phosphateReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. 1-acylglycerol-3-phosphate pool formation and breakdown

  Catalysed by GPAT3, GPAT2, GPAT4, GPAMmitochondrial matrix, cytosolOne of 3 routes

• 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by AGPAT2, GPAT3, LPCAT2, AGPAT1 and 1 morecytosol

• 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoAReach from here →
  1. acyl-CoA pool formation and breakdown
  2. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA

  Catalysed by ELOVL4cytosol

• 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + (9Z,12Z)-octadecadienoyl-CoA = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by LPCAT3cytosol

• (2E)-eicosenoyl-CoAReach from here →
  1. acyl-CoA pool formation and breakdown
  2. acyl-CoA oxidase (eicosanoyl-CoA)

  Catalysed by ACOX3, ACOX1cytosol, peroxisomeOne of 4 routes

• (2E)-docosenoyl-CoAReach from here →
  1. acyl-CoA pool formation and breakdown
  2. acyl-CoA oxidase (docosanoyl-CoA)

  Catalysed by ACOX3, ACOX1cytosol, peroxisomeOne of 4 routes

• (2E)-tetracosenoyl-CoAReach from here →
  1. acyl-CoA pool formation and breakdown
  2. acyl-CoA oxidase (tetracosanoyl-CoA)

  Catalysed by ACOX3, ACOX1cytosol, peroxisomeOne of 3 routes

• 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. (9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by AGPAT1cytosol

• 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + (9Z,12Z)-octadecadienoyl-CoA = 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serine + CoA

  Catalysed by LPCAT3, MBOAT1cytosol

• 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + (9Z)-hexadecenoyl-CoA = 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA

  Catalysed by MBOAT1cytosol

• 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA

  Catalysed by MBOAT1, LPGAT1cytosol

• a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphateReach from here →
  1. sn-glycerol 3-phosphate + an acyl-CoA = a 1-acyl-sn-glycero-3-phosphate + CoA
  2. a 1-acyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = a 1-acyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 1 more

• 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. eicosanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by ABHD5cytosol

• 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphateReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. 1-acylglycerol-3-phosphate pool formation and breakdown

  Catalysed by GPAT3, GPAT2, GPAT4, GPAMmitochondrial matrix, cytosolOne of 2 routes

• 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by LPCAT1cytosol

• 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by LPGAT1cytosol

• 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoyl-CoA = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by LPCAT3cytosol

• 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. dodecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by LPCAT3, LPCAT1cytosol

• 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + (9Z,12Z)-octadecadienoyl-CoA = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA

  Catalysed by LPCAT3cytosol

• 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by LPGAT1cytosol

• 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by LPGAT1cytosol

• 1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-acyl-sn-glycero-3-phospho-L-serine + (9Z,12Z)-octadecadienoyl-CoA = 1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA

  Catalysed by LPCAT3cytosol

• 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-acyl-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoyl-CoA = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by LPCAT3cytosol

• 1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + dodecanoyl-CoA = 1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by AGPAT1cytosol

• 1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. nonadecanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by LPCAT2, AGPAT3, AGPAT5cytosol

• (11Z)-octadecenoyl-CoAReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 3 moremitochondrial matrix, cytosolOne of 4 routes

• 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by LCLAT1cytosol

• 1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA = 1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA

  Catalysed by LCLAT1cytosol

• 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA

  Catalysed by LCLAT1cytosol

• 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerol + CoA

  Catalysed by LCLAT1cytosol

• 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA = 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA

  Catalysed by LCLAT1cytosol

• 1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoyl-CoA = 1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA

  Catalysed by LCLAT1cytosol

• 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by LPCAT4cytosol

• 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. tetradecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by LPCAT1cytosol

• 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA = 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by MOGAT2, MOGAT1cytosol

• 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA = 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by MOGAT2, MOGAT1cytosol

• 1-octadecanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by MOGAT2, MOGAT1cytosol

• 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 2-(9Z-octadecenoyl)-glycerol + (9Z,12Z)-octadecadienoyl-CoA = 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by MOGAT2, MOGAT1cytosol

• eicosan-1-olReach from here →
  1. acyl-CoA pool formation and breakdown
  2. eicosanoyl-CoA + 2 NADPH + 2 H(+) = eicosan-1-ol + 2 NADP(+) + CoA

  Catalysed by FAR1, FAR2cytosol

• hexadecyl (9Z)-hexadecenoateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. hexadecan-1-ol + (9Z)-hexadecenoyl-CoA = hexadecyl (9Z)-hexadecenoate + CoA

  Catalysed by AWAT1, AWAT2cytosol

• hexadecyl octadecanoateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. hexadecan-1-ol + octadecanoyl-CoA = hexadecyl octadecanoate + CoA

  Catalysed by AWAT1, AWAT2cytosol

• dodecanedioyl-CoAReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. Activation of dodecanedioic acid

  Catalysed by GPAT3, GPAT2, GPAT4, GPAMmitochondrial matrix, cytosolOne of 4 routes

• decanedioyl-CoAReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. Production of Sebacoylcarnitine

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 3 moremitochondrial matrix, cytosolOne of 4 routes

• octanedioyl-CoAReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. Production of Suberylcarnitine

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 3 moremitochondrial matrix, cytosolOne of 4 routes

• hexanedioyl-CoAReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. Activation of adipic acid for Formation of Adipoyl Carnitine

  Catalysed by GPAT3, GPAT2, GPAT4, GPAMmitochondrial matrix, cytosolOne of 4 routes

• (2E,8Z,11Z,14Z)-eicosatetraenoyl-CoAReach from here →
  1. acyl-CoA pool formation and breakdown
  2. ELOVL fatty acid elongase (trans-2-cis,cis,cis-8,11,14-eicosatetraenoyl-CoA)

  Catalysed by ELOVL1cytosol, endoplasmic reticulumOne of 2 routes

• 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
  2. a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)

  Catalysed by LCLAT1, LPCAT1, GPAM, PLA2G15 and 1 moreOne of 2 routes

• 3-oxo-(11Z)-octadecenoyl-CoAReach from here →
  1. acyl-CoA pool formation and breakdown
  2. (9Z)-hexadecenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA

  Catalysed by ELOVL6, ELOVL5cytosol

• (R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. Production of 3-Hydroxyoctadecenoylcarnitinec

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 3 moremitochondrial matrix, cytosolOne of 2 routes