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Reach

(S)-2-amino-6-oxohexanoate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

78 compounds within 3 steps: 1 in 1, 2 in 2, 75 in 3

Does it reach a compound?

Three steps

glycochenodeoxycholic acidReach from here →
1. (S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)
2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
3. bile acid-CoA: amino acid N-acyltransferase
Catalysed by ALDH7A1, AADAT, BAATperoxisomeOne of 3 routes
glyoxylateReach from here →
1. (S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)
2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
Catalysed by ALDH7A1, AADATOne of 11 routes
glycolithocholic acidReach from here →
1. (S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)
2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
3. bile acid-CoA:amino acid N-acyltransferase (glycine)
Catalysed by ALDH7A1, AADAT, BAATcytosolOne of 2 routes
L-2-amino-3-oxobutanoic acidReach from here →
1. (S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)
2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
3. Acetyl-CoA:glycine C-acetyltransferase
Catalysed by ALDH7A1, AADAT, GCATmitochondrial matrix
L-ornithineReach from here →
1. (S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)
2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
3. L-Arginine:glycine amidinotransferase
Catalysed by ALDH7A1, AADAT, GATMcytosolOne of 5 routes
S(8)-aminomethyldihydrolipoamideReach from here →
1. (S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)
2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)
Catalysed by ALDH7A1, AADAT, GLDC, GCSHmitochondrial matrix
sarcosineReach from here →
1. (S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)
2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
Catalysed by ALDH7A1, AADAT, PIPOXOne of 2 routes
(6S)-5,6,7,8-tetrahydrofolateReach from here →
1. (S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)
2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
Catalysed by ALDH7A1, AADAT, SHMT1, SHMT2
an N-acylglycineReach from here →
1. (S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)
2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)
Catalysed by ALDH7A1, AADAT, GLYATL3, GLYAT and 1 more
guanidinoacetateReach from here →
1. (S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)
2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
3. L-Arginine:glycine amidinotransferase
Catalysed by ALDH7A1, AADAT, GATMcytosolOne of 2 routes
L-methionineReach from here →
1. (S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)
2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
3. transport of glycine and methionine (cytosol to extracellular)
Catalysed by ALDH7A1, AADAT, SLC7A5extracellular space, cytosolOne of 5 routes
L-tryptophanReach from here →
1. (S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)
2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
3. transport of glycine and tryptophan (cytosol to extracellular)
Catalysed by ALDH7A1, AADAT, SLC7A5extracellular space, cytosolOne of 5 routes
glutathioneReach from here →
1. (S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)
2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
3. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
Catalysed by ALDH7A1, AADAT, GSS
L-alanineReach from here →
1. (S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)
2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
3. transport of alanine and glycine (cytosol to extracellular)
Catalysed by ALDH7A1, AADAT, SLC3A2, SLC7A5 and 1 moreextracellular space, cytosolOne of 6 routes
leukotriene C4Reach from here →
1. (S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)
2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
3. leukotriene C4 hydrolysis
Catalysed by ALDH7A1, AADATcytosol
L-asparagineReach from here →
1. (S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)
2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
3. transport of asparagine and glycine (cytosol to extracellular)
Catalysed by ALDH7A1, AADATextracellular space, cytosolOne of 4 routes
L-phenylalanineReach from here →
1. (S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)
2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
3. transport of glycine and phenylalanine (cytosol to extracellular)
Catalysed by ALDH7A1, AADAT, SLC7A5extracellular space, cytosolOne of 7 routes
L-tyrosineReach from here →
1. (S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)
2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
Catalysed by ALDH7A1, AADAT
N(omega),N(omega)-dimethyl-L-arginineReach from here →
1. (S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)
2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
3. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine
Catalysed by ALDH7A1, AADAT, AGXT2
kynurenateReach from here →
1. (S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)
2. L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate
3. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O
Catalysed by ALDH7A1, AADAT
N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
1. (S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)
2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
Catalysed by ALDH7A1, AADAT, GLYATL2One of 2 routes
N-benzoylglycineReach from here →
1. (S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)
2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
3. Hippurate (Benzoylglycinate) Formation
Catalysed by ALDH7A1, AADATmitochondrial matrixOne of 2 routes
(2S)-2-aminobutanoateReach from here →
1. (S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)
2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
3. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
Catalysed by ALDH7A1, AADAT, AGXT2
glycodeoxycholateReach from here →
1. (S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)
2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
3. Glycodeoxycholate amidohydrolase
Catalysed by ALDH7A1, AADATcytosolOne of 2 routes
N-tetradecanoylglycineReach from here →
1. (S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)
2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
Catalysed by ALDH7A1, AADAT, GLYATL2
N-eicosanoylglycinateReach from here →
1. (S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)
2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)
Catalysed by ALDH7A1, AADAT, BAAT
N-docosanoylglycineReach from here →
1. (S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)
2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)
Catalysed by ALDH7A1, AADAT, BAAT
N-hexacosanoylglycineReach from here →
1. (S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)
2. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine
3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)
Catalysed by ALDH7A1, AADAT, BAAT

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