spermidine
362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API
603 compounds within 3 steps: 14 in 1, 119 in 2, 470 in 3
Three steps
- diamine N-acetyltransferase (N1-acetylspermidine)
- Palmitate:CoA ligase (AMP-forming)
- very-long-chain 3-oxoacyl-CoA synthase (malonyl-CoA)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 13 morecytosolOne of 2 routes
- diamine N-acetyltransferase (N1-acetylspermidine)
- long-chain-fatty-acid-CoA ligase (eicosanoate)
- very-long-chain 3-oxoacyl-CoA synthase (eicosanoyl-CoA)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 13 morecytosolOne of 3 routes
Catalysed by SAT1, SAT2, CPT1A, CPT1C and 1 morecytosol, endoplasmic reticulumOne of 2 routes
- diamine N-acetyltransferase (N1-acetylspermidine)
- long-chain-fatty-acid-CoA ligase (lauric acid)
- glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 10 morecytosolOne of 2 routes
- diamine N-acetyltransferase (N1-acetylspermidine)
- acyl-CoA:sphingosine N-acyltransferase
- N-dodecanoylsphing-4-enine + H2O = dodecanoate + sphing-4-enine
Catalysed by SAT1, SAT2, ASAH1, ACER2 and 3 morecytosol, Golgi apparatus
- diamine N-acetyltransferase (N1-acetylspermidine)
- acyl-CoA:sphingosine N-acyltransferase
- N-tetradecanoylsphing-4-enine + H2O = sphing-4-enine + tetradecanoate
Catalysed by SAT1, SAT2, ASAH1, ACER2 and 2 morecytosol, Golgi apparatus
- diamine N-acetyltransferase (N1-acetylspermidine)
- acyl-CoA:sphingosine N-acyltransferase
- sphing-4-enine + hexadecanoyl-CoA = N-hexadecanoylsphing-4-enine + CoA + H(+)
Catalysed by SAT1, SAT2, ASAH1, ACER2 and 6 morecytosol, Golgi apparatusOne of 2 routes
- diamine N-acetyltransferase (N1-acetylspermidine)
- long-chain-fatty-acid-CoA ligase (stearate)
- sphing-4-enine + octadecanoyl-CoA = N-octadecanoylsphing-4-enine + CoA + H(+)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 9 morecytosolOne of 3 routes
- diamine N-acetyltransferase (N1-acetylspermidine)
- long-chain-fatty-acid-CoA ligase (eicosanoate)
- eicosanoyl-CoA + sphing-4-enine = N-eicosanoyl-sphing-4-enine + CoA + H(+)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 8 morecytosolOne of 2 routes
- diamine N-acetyltransferase (N1-acetylspermidine)
- long-chain-fatty-acid-CoA ligase (lignocerate)
- tetracosanoyl-CoA + sphing-4-enine = N-tetracosanoyl-sphing-4-enine + CoA + H(+)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 7 morecytosolOne of 2 routes
- S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
- acetyl-CoA:putrescine N-acetyltransferase
- N-Acetylputrescine:oxygen oxidoreductase(deaminating)(flavin-containing)
Catalysed by SRM, SAT1, SAT2, AOC2 and 4 morecytosolOne of 2 routes
- diamine N-acetyltransferase (N1-acetylspermidine)
- long-chain-fatty-acid-CoA ligase (behenic acid)
- very-long-chain 3-oxoacyl-CoA synthase (docosanoyl-CoA)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 13 morecytosolOne of 3 routes
- diamine N-acetyltransferase (N1-acetylspermidine)
- long-chain-fatty-acid-CoA ligase (lignocerate)
- very-long-chain 3-oxoacyl-CoA synthase (malonyl-CoA)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 13 morecytosolOne of 3 routes
- diamine N-acetyltransferase (N1-acetylspermidine)
- long-chain-fatty-acid-CoA ligase (cerotic acid)
- acyl-CoA oxidase (hexacosanoyl-CoA)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 8 morecytosol, peroxisomeOne of 2 routes
- diamine N-acetyltransferase (N1-acetylspermidine)
- glycine N-acyltransferase (N-arachidonoylglycine)
- (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
Catalysed by SAT1, SAT2, GLYAT, GLYATL2 and 2 morecytosol, mitochondrial matrixOne of 2 routes
- diamine N-acetyltransferase (N1-acetylspermidine)
- acyl-CoA:sphingosine N-acyltransferase
- N-(15Z-tetracosenoyl)-sphing-4-enine + H2O = (15Z)-tetracosenoate + sphing-4-enine
Catalysed by SAT1, SAT2, ASAH1, ACER2 and 2 morecytosol, Golgi apparatus
- diamine N-acetyltransferase (N1-acetylspermidine)
- acyl-CoA:sphingosine N-acyltransferase
- tetracosenoyl-CoA + sphing-4-enine = N-(tetracosenoyl)-sphing-4-enine + CoA + H(+)
Catalysed by SAT1, SAT2, ASAH1, ACER2 and 3 morecytosol, Golgi apparatus
- diamine N-acetyltransferase (N1-acetylspermidine)
- long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
- glycerol-3-phosphate 1-O-acyltransferase (linoleoyl-CoA)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 10 morecytosolOne of 2 routes
- diamine N-acetyltransferase (N1-acetylspermidine)
- long-chain-fatty-acid-CoA ligase (stearate)
- glycerol-3-phosphate 1-O-acyltransferase (sn-glycerol-3-phosphate)
Catalysed by SAT1, SAT2, SLC27A2, ACSL4 and 9 morecytosolOne of 2 routes