AH2

Three steps

• hexadecanedioyl-CoAReach from here →
  1. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Production of Hexadecanedioylcarnitine

  Catalysed by SCLY, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 2 routes

• pristanoyl-CoAReach from here →
  1. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. fatty-acid-CoA ligase

  Catalysed by SCLY, SLC27A2mitochondrial matrix, cytosolOne of 2 routes

• a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholineReach from here →
  1. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
  2. 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine

  Catalysed by PTGS2, PLA2G4A, TMEM86A, TMEM86B

• undecanoyl-CoAReach from here →
  1. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. medium-chain acyl-CoA ligase (undecylic acid)

  Catalysed by SCLY, ACSM4, ACSM1, ACSM2A and 3 moremitochondrial matrix, cytosolOne of 3 routes

• 9-cis-retinolReach from here →
  1. A + NADH + H(+) = AH2 + NAD(+)
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. retinol binding protein (retinol)

  Catalysed by AIFM1, PYROXD1, RETSAT, RBP1 and 1 morecytosolOne of 2 routes

• ursodeoxycholateReach from here →
  1. 3,3',5-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and ursodeoxycholate (cytosol to extracellular)

  Catalysed by DIO1, DIO2, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• 7alpha,25-dihydroxy-4-cholesten-3-oneReach from here →
  1. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
  2. cytochrome P450 (25-hydroxycholesterol)
  3. cholest-5-ene-3beta,7alpha,25-triol:NAD+ 3-oxidoreductase

  Catalysed by CH25H, CYP7B1, HSD3B7endoplasmic reticulumOne of 2 routes

• prostaglandin G2Reach from here →
  1. 3,3',5-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and prostaglandin G2 (cytosol to extracellular)

  Catalysed by DIO1, DIO2, SLCO1A2, SLCO1B3 and 1 moreextracellular space, cytosolOne of 4 routes

• glycodeoxycholateReach from here →
  1. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  2. L-Alanine:glyoxylate aminotransferase
  3. Glycodeoxycholate amidohydrolase

  Catalysed by SCLY, AGXT, AGXT2mitochondrial matrix, cytosolOne of 2 routes

• (5Z)-tetradecenoyl-CoAReach from here →
  1. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (physeteric acid)

  Catalysed by SCLY, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 8 routes

• (3E)-decenoyl-CoAReach from here →
  1. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

  Catalysed by SCLY, ACADM, ECHS1, ACAA2 and 1 moremitochondrial matrix

• 11beta-prostaglandin F2Reach from here →
  1. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O
  2. prostaglandin-D synthase (prostaglandin H2)
  3. prostaglandin D2 + NADPH + H(+) = 11beta-prostaglandin F2 + NADP(+)

  Catalysed by PTGS1, PTGS2, HPGDS, PTGDS and 2 morecytosol

• N-tetradecanoylglycineReach from here →
  1. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  2. L-Alanine:glyoxylate aminotransferase
  3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

  Catalysed by SCLY, AGXT, AGXT2, GLYATL2mitochondrial matrix

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by SCLY, HADHA, ACAA2, HADHBmitochondrial matrix

• N-eicosanoylglycinateReach from here →
  1. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  2. L-Alanine:glyoxylate aminotransferase
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by SCLY, AGXT, AGXT2, BAATmitochondrial matrix

• N-docosanoylglycineReach from here →
  1. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  2. L-Alanine:glyoxylate aminotransferase
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by SCLY, AGXT, AGXT2, BAATmitochondrial matrix

• N-hexacosanoylglycineReach from here →
  1. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  2. L-Alanine:glyoxylate aminotransferase
  3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

  Catalysed by SCLY, AGXT, AGXT2, BAATmitochondrial matrix

• an N(2)-acyl-L-glutamineReach from here →
  1. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  2. transport of alanine and glutamine (cytosol to extracellular)
  3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by SCLY, SLC3A2, SLC7A5, SLC7A10 and 2 moreextracellular space, cytosol

• (7Z)-hexadecenoyl-CoAReach from here →
  1. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by SCLY, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 8 routes

• tricosanoyl-CoAReach from here →
  1. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by SCLY, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 4 routes

• Se-methylselenocysteineReach from here →
  1. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. S-Adenosyl-L-methionine:thiol S-methyltransferase

  Catalysed by SCLYcytosol

• thromboxane B2Reach from here →
  1. 3,3',5-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. transport of GSH and thromboxane B2 (cytosol to extracellular)

  Catalysed by DIO1, DIO2, SLCO1A2, SLCO1B3 and 1 moreextracellular space, cytosolOne of 8 routes

• taurochenodeoxycholateReach from here →
  1. 3,3',5-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
  2. transport of GSH and triiodothyronine (cytosol to extracellular)
  3. solute carrier organic anion transporter (GSH)

  Catalysed by DIO1, DIO2, SLCO1A2, SLCO1B3 and 1 moreextracellular space, cytosolOne of 4 routes

• 2-(1-hydroxyethyl)thiamine diphosphateReach from here →
  1. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

  Catalysed by SCLY, AGXT2, PDHA1, PDHB and 1 moremitochondrial matrix