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Proteins/UNIPROT:Q8NBI2
Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce iron cations Fe(3+) into Fe(2+) in the lumen of the late endosome and lysosome. Reduced iron can then be extruded from the late endosome and lysosome to the cytoplasm by divalent metal-specific transporters. It is therefore most probably involved in endosomal and lysosomal cellular iron homeostasis..
Function from UniProtKB (Q8NBI2), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
16 statements
16 statements · 4 reference databases · Subject: CYB561A3 · Sources: Bgee, Hetionet, Rhea, UniProt
1 reaction
Fe(3+)+L-ascorbic acidmonodehydro-L-ascorbate radical+iron(2+)+hydron
Catalysed by CYB561D2 or CYB561 or CYBRD1 or CYB561D1 or CYB561A3
Reaction pageLeft to rightBalanced
Rhea RHEA:30403CC BY 4.0Reference data
5 names
Resolves to: CYB561A3