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Proteins/UNIPROT:Q8NB49
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane. Major PS-flippase in immune cell subsets. In erythrocyte plasma membrane, it is required to maintain PS in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for erythrocyte clearance by splenic macrophages. Required for B cell differentiation past the pro-B cell stage (By similarity). Seems to mediate PS flipping in pro-B cells (By similarity). May be involved in the transport of cholestatic bile acids (By similarity)..
Function from UniProtKB (Q8NB49), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
12 statements
12 statements · 6 reference databases · Subject: ATP11C · Sources: Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
17 reactions
ATP+water+MAM03838cADP+proton+phosphate(3-)+MAM03838e
Transported by ATP11A or ATP11C
Reaction pageLeft to rightBalancedEC 7.6.2.1cytosol, extracellular space
Human-GEM MAR11613CC BY 4.0Reference data
5 names
Resolves to: ATP11C
Reaction pageLeft to rightBalancedEC 7.6.2.1cytosol, extracellular space
Human-GEM MAR11614CC BY 4.0Reference data
ATP+water+MAM03840cADP+proton+phosphate(3-)+MAM03840e
Transported by ATP11A or ATP11C
Reaction pageLeft to rightBalancedEC 7.6.2.1cytosol, extracellular space
Human-GEM MAR11615CC BY 4.0Reference data
ATP+water+MAM03841cADP+proton+phosphate(3-)+MAM03841e
Transported by ATP11A or ATP11C
Reaction pageLeft to rightBalancedEC 7.6.2.1cytosol, extracellular space
Human-GEM MAR11616CC BY 4.0Reference data
ATP+water+MAM03842cADP+proton+phosphate(3-)+MAM03842e
Transported by ATP11A or ATP11C
Reaction pageLeft to rightBalancedEC 7.6.2.1cytosol, extracellular space
Human-GEM MAR11617CC BY 4.0Reference data
ATP+water+MAM03843cADP+proton+phosphate(3-)+MAM03843e
Transported by ATP11A or ATP11C
Reaction pageLeft to rightBalancedEC 7.6.2.1cytosol, extracellular space
Human-GEM MAR11618CC BY 4.0Reference data
ATP+water+MAM03844cADP+proton+phosphate(3-)+MAM03844e
Transported by ATP11A or ATP11C
Reaction pageLeft to rightBalancedEC 7.6.2.1cytosol, extracellular space
Human-GEM MAR11619CC BY 4.0Reference data
ATP+water+MAM03846cADP+proton+phosphate(3-)+MAM03846e
Transported by ATP11A or ATP11C
Reaction pageLeft to rightBalancedEC 7.6.2.1cytosol, extracellular space
Human-GEM MAR11620CC BY 4.0Reference data
ATP+water+2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamineADP+proton+phosphate(3-)+2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine
Transported by ATP11A or ATP11C
Reaction pageLeft to rightBalancedEC 7.6.2.1cytosol, extracellular space
Human-GEM MAR11621CC BY 4.0Reference data
ATP+water+MAM03848cADP+proton+phosphate(3-)+MAM03848e
Transported by ATP11A or ATP11C
Reaction pageLeft to rightBalancedEC 7.6.2.1cytosol, extracellular space
Human-GEM MAR11622CC BY 4.0Reference data
ATP+water+MAM03855cADP+proton+phosphate(3-)+MAM03855e
Transported by ATP11A or ATP11C
Reaction pageLeft to rightBalancedEC 7.6.2.1cytosol, extracellular space
Human-GEM MAR11623CC BY 4.0Reference data
ATP+water+MAM03856cADP+proton+phosphate(3-)+MAM03856e
Transported by ATP11A or ATP11C
Reaction pageLeft to rightBalancedEC 7.6.2.1cytosol, extracellular space
Human-GEM MAR11624CC BY 4.0Reference data