Loading the page.
Proteins/UNIPROT:P98196
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane. Does not show flippase activity toward phosphatidylcholine (PC). Contributes to the maintenance of membrane lipid asymmetry with a specific role in morphogenesis of muscle cells. In myoblasts, mediates PS enrichment at the inner leaflet of plasma membrane, triggering PIEZO1-dependent Ca2+ influx and Rho GTPases signal transduction, subsequently leading to the assembly of cortical actomyosin fibers and myotube formation. May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib..
Function from UniProtKB (P98196), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
5 rows
23 statements
23 statements · 7 reference databases · Subject: ATP11A · Sources: Bgee, gene ontology, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
17 reactions
ATP+water+MAM03838cADP+proton+phosphate(3-)+MAM03838e
Transported by ATP11A or ATP11C
Reaction pageLeft to rightBalancedEC 7.6.2.1cytosol, extracellular space
Human-GEM MAR11613CC BY 4.0Reference data
6 names
Resolves to: ATP11A
Reaction pageLeft to rightBalancedEC 7.6.2.1cytosol, extracellular space
Human-GEM MAR11614CC BY 4.0Reference data
ATP+water+MAM03840cADP+proton+phosphate(3-)+MAM03840e
Transported by ATP11A or ATP11C
Reaction pageLeft to rightBalancedEC 7.6.2.1cytosol, extracellular space
Human-GEM MAR11615CC BY 4.0Reference data
ATP+water+MAM03841cADP+proton+phosphate(3-)+MAM03841e
Transported by ATP11A or ATP11C
Reaction pageLeft to rightBalancedEC 7.6.2.1cytosol, extracellular space
Human-GEM MAR11616CC BY 4.0Reference data
ATP+water+MAM03842cADP+proton+phosphate(3-)+MAM03842e
Transported by ATP11A or ATP11C
Reaction pageLeft to rightBalancedEC 7.6.2.1cytosol, extracellular space
Human-GEM MAR11617CC BY 4.0Reference data
ATP+water+MAM03843cADP+proton+phosphate(3-)+MAM03843e
Transported by ATP11A or ATP11C
Reaction pageLeft to rightBalancedEC 7.6.2.1cytosol, extracellular space
Human-GEM MAR11618CC BY 4.0Reference data
ATP+water+MAM03844cADP+proton+phosphate(3-)+MAM03844e
Transported by ATP11A or ATP11C
Reaction pageLeft to rightBalancedEC 7.6.2.1cytosol, extracellular space
Human-GEM MAR11619CC BY 4.0Reference data
ATP+water+MAM03846cADP+proton+phosphate(3-)+MAM03846e
Transported by ATP11A or ATP11C
Reaction pageLeft to rightBalancedEC 7.6.2.1cytosol, extracellular space
Human-GEM MAR11620CC BY 4.0Reference data
ATP+water+2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamineADP+proton+phosphate(3-)+2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine
Transported by ATP11A or ATP11C
Reaction pageLeft to rightBalancedEC 7.6.2.1cytosol, extracellular space
Human-GEM MAR11621CC BY 4.0Reference data
ATP+water+MAM03848cADP+proton+phosphate(3-)+MAM03848e
Transported by ATP11A or ATP11C
Reaction pageLeft to rightBalancedEC 7.6.2.1cytosol, extracellular space
Human-GEM MAR11622CC BY 4.0Reference data
ATP+water+MAM03855cADP+proton+phosphate(3-)+MAM03855e
Transported by ATP11A or ATP11C
Reaction pageLeft to rightBalancedEC 7.6.2.1cytosol, extracellular space
Human-GEM MAR11623CC BY 4.0Reference data
ATP+water+MAM03856cADP+proton+phosphate(3-)+MAM03856e
Transported by ATP11A or ATP11C
Reaction pageLeft to rightBalancedEC 7.6.2.1cytosol, extracellular space
Human-GEM MAR11624CC BY 4.0Reference data