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Proteins/UNIPROT:Q9H0X9
Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes. Binds 25-hydroxycholesterol and cholesterol..
Function from UniProtKB (Q9H0X9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
20 statements
20 statements · 5 reference databases · Subject: OSBPL5 · Sources: Bgee, Hetionet, Reactome, Rhea, WikiPathways
1 reaction
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+a 1,2-diacyl-sn-glycero-3-phospho-L-serinea 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+a 1,2-diacyl-sn-glycero-3-phospho-L-serine
Transported by OSBPL9 or OSBPL11 or OSBPL10 or OSBPL8 or OSBPL6 or OSBPL5
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:81667CC BY 4.0Reference data
6 names
Resolves to: OSBPL5