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Proteins/UNIPROT:O43520
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phospholipids, in particular phosphatidylcholines (PC), from the outer to the inner leaflet of the plasma membrane. May participate in the establishment of the canalicular membrane integrity by ensuring asymmetric distribution of phospholipids in the canicular membrane (By similarity). Thus may have a role in the regulation of bile acids transport into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both and protect hepatocytes from bile salts (By similarity). Involved in the microvillus formation in polarized epithelial cells; the function seems to be independent from its flippase activity. Participates in correct apical membrane localization of CDC42, CFTR and SLC10A2. Enables CDC42 clustering at the apical membrane during enterocyte polarization through the interaction between CDC42 polybasic region and negatively charged membrane lipids provided by ATP8B1 (By similarity). Together with CDC50A is involved in uptake of the synthetic drug alkylphospholipid perifosine. Required for the preservation of cochlear hair cells in the inner ear (By similarity). May act as cardiolipin transporter during inflammatory injury (By similarity)..
Function from UniProtKB (O43520), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
100 statements
100 statements · 9 reference databases · Subject: ATP8B1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
31 reactions
MAM00516c+ATP+waterMAM00516e+ADP+proton+phosphate(3-)
Transported by ABCB4 or ATP8B1 or ATP8B2 or ABCA1 or ATP10A
Reaction pageLeft to rightBalance undeterminableEC 7.6.2.2, 7.6.2.1cytosol, extracellular space
Human-GEM MAR11572CC BY 4.0Reference data
6 names
Resolves to: ATP8B1
Reaction pageLeft to rightBalance undeterminableEC 7.6.2.2, 7.6.2.1cytosol, extracellular space
Human-GEM MAR11582CC BY 4.0Reference data
ATP+water+MAM03827cADP+proton+phosphate(3-)+MAM03827e
Transported by ABCB4 or ATP8B1 or ATP8B2 or ABCA1 or ATP10A
Reaction pageLeft to rightBalancedEC 7.6.2.2, 7.6.2.1cytosol, extracellular space
Human-GEM MAR11587CC BY 4.0Reference data
ATP+water+MAM03805cADP+proton+phosphate(3-)+MAM03805e
Transported by ABCB4 or ATP8B1 or ATP8B2 or ABCA1 or ATP10A
Reaction pageLeft to rightBalancedEC 7.6.2.2, 7.6.2.1cytosol, extracellular space
Human-GEM MAR11588CC BY 4.0Reference data
ATP+water+MAM03806cADP+proton+phosphate(3-)+MAM03806e
Transported by ABCB4 or ATP8B1 or ATP8B2 or ABCA1 or ATP10A
Reaction pageLeft to rightBalancedEC 7.6.2.2, 7.6.2.1cytosol, extracellular space
Human-GEM MAR11589CC BY 4.0Reference data
ATP+water+MAM03808cADP+proton+phosphate(3-)+MAM03808e
Transported by ABCB4 or ATP8B1 or ATP8B2 or ABCA1 or ATP10A
Reaction pageLeft to rightBalancedEC 7.6.2.2, 7.6.2.1cytosol, extracellular space
Human-GEM MAR11590CC BY 4.0Reference data
ATP+water+1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholineADP+proton+phosphate(3-)+1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine
Transported by ABCB4 or ATP8B1 or ATP8B2 or ABCA1 or ATP10A
Reaction pageLeft to rightBalancedEC 7.6.2.2, 7.6.2.1cytosol, extracellular space
Human-GEM MAR11591CC BY 4.0Reference data
ATP+water+MAM03810cADP+proton+phosphate(3-)+MAM03810e
Transported by ABCB4 or ATP8B1 or ATP8B2 or ABCA1 or ATP10A
Reaction pageLeft to rightBalancedEC 7.6.2.2, 7.6.2.1cytosol, extracellular space
Human-GEM MAR11592CC BY 4.0Reference data
ATP+water+MAM03811cADP+proton+phosphate(3-)+MAM03811e
Transported by ABCB4 or ATP8B1 or ATP8B2 or ABCA1 or ATP10A
Reaction pageLeft to rightBalancedEC 7.6.2.2, 7.6.2.1cytosol, extracellular space
Human-GEM MAR11593CC BY 4.0Reference data
ATP+water+MAM03812cADP+proton+phosphate(3-)+MAM03812e
Transported by ABCB4 or ATP8B1 or ATP8B2 or ABCA1 or ATP10A
Reaction pageLeft to rightBalancedEC 7.6.2.2, 7.6.2.1cytosol, extracellular space
Human-GEM MAR11594CC BY 4.0Reference data
ATP+water+MAM03813cADP+proton+phosphate(3-)+MAM03813e
Transported by ABCB4 or ATP8B1 or ATP8B2 or ABCA1 or ATP10A
Reaction pageLeft to rightBalancedEC 7.6.2.2, 7.6.2.1cytosol, extracellular space
Human-GEM MAR11595CC BY 4.0Reference data
ATP+water+1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholineADP+proton+phosphate(3-)+1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine
Transported by ABCB4 or ATP8B1 or ATP8B2 or ABCA1 or ATP10A
Reaction pageLeft to rightBalancedEC 7.6.2.2, 7.6.2.1cytosol, extracellular space
Human-GEM MAR11596CC BY 4.0Reference data