Pathway
EGFR interacts with phospholipase C-gamma
Activated epidermal growth factor receptors (EGFR) can stimulate phosphatidylinositol (PI) turnover. Activated EGFR can activate phospholipase C-gamma1 (PLC-gamma1, i.e. PLCG1) which hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). IP3 is instrumental in the release of calcium from intracellular stores and DAG is involved in protein kinase C activation.
REACT:R-HSA-212718Reactome
What the reference databases state
Statements
8 statements
8 statements · 1 reference database · Subject: EGFR interacts with phospholipase C-gamma · Sources: Reactome
- AREG participates in EGFR interacts with phospholipase C-gammaProteinReactome R-HSA-212718Inferred only
- BTC participates in EGFR interacts with phospholipase C-gammaProteinReactome R-HSA-212718Inferred only
- EGF participates in EGFR interacts with phospholipase C-gammaProteinReactome R-HSA-212718Inferred only
- EGFR participates in EGFR interacts with phospholipase C-gammaProteinReactome R-HSA-212718Inferred only
- EREG participates in EGFR interacts with phospholipase C-gammaProteinReactome R-HSA-212718Inferred only
- HBEGF participates in EGFR interacts with phospholipase C-gammaProteinReactome R-HSA-212718Inferred only
- PLCG1 participates in EGFR interacts with phospholipase C-gammaProteinReactome R-HSA-212718Inferred only
- TGFA participates in EGFR interacts with phospholipase C-gammaProteinReactome R-HSA-212718Inferred only