tooth agenesis
MONDO:0005486Mondo
Findings
No curated finding names tooth agenesis yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A tooth disease characterized by failure to develop one or more missing teeth.
Definition from the Mondo Disease Ontology (MONDO:0005486), read 2026-09-29. CC BY 4.0.
Features
23 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- OligodontiaHPOHP:0000677
- Obligate (100% of cases)
- Impaired masticationHPOHP:0005216
- Very frequent (80% to 99% of cases)
- Agenesis of central incisorHPOHP:0006289
- Frequent (30% to 79% of cases)
- Agenesis of first permanent molar toothHPOHP:0011056
- Frequent (30% to 79% of cases)
- Agenesis of maxillary lateral incisorHPOHP:0000690
- Frequent (30% to 79% of cases)
- Agenesis of premolarHPOHP:0011051
- Frequent (30% to 79% of cases)
- Delayed eruption of permanent teethHPOHP:0000696
- Frequent (30% to 79% of cases)
- Delayed eruption of teethHPOHP:0000684
- Frequent (30% to 79% of cases)
- Dental malocclusionHPOHP:0000689
- Frequent (30% to 79% of cases)
- MicrodontiaHPOHP:0000691
- Frequent (30% to 79% of cases)
- Short dental rootHPOHP:0006336
- Frequent (30% to 79% of cases)
- Widely spaced teethHPOHP:0000687
- Frequent (30% to 79% of cases)
Show the remaining 11
- Abnormal canine tooth morphologyHPOHP:0011078
- Occasional (5% to 29% of cases)
- Abnormal dental morphologyHPOHP:0006482
- Occasional (5% to 29% of cases)
- Abnormal primary molar morphologyHPOHP:0006344
- Occasional (5% to 29% of cases)
- Agenesis of mandibular premolarHPOHP:0011053
- Occasional (5% to 29% of cases)
- EclabionHPOHP:0012472
- Occasional (5% to 29% of cases)
- Enamel hypoplasiaHPOHP:0006297
- Occasional (5% to 29% of cases)
Genes
10 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- LRP6HGNC:6698
- Definitive · Illumina · Autosomal dominant · 2021
- Supportive · Orphanet · Autosomal dominant · 2021
- EDAHGNC:3157
- Supportive · Orphanet · Autosomal dominant · 2021
- EDARADDHGNC:14341
- Supportive · Orphanet · Autosomal dominant · 2021
- FGFR1HGNC:3688
- Supportive · Orphanet · Autosomal dominant · 2021
- IRF6HGNC:6121
- Supportive · Orphanet · Autosomal dominant · 2021
Where it sits
- A kind of
- Narrower terms (12)
- hypodontia/oligodontia with orofacial cleft
- tooth agenesis, selective, 1
- tooth agenesis, selective, 10
- tooth agenesis, selective, 2
- tooth agenesis, selective, 3
- tooth agenesis, selective, 4
- tooth agenesis, selective, 5
- tooth agenesis, selective, 7
- tooth agenesis, selective, 8
- tooth agenesis, selective, 9
- tooth agenesis, selective, with orofacial cleft
- tooth agenesis, selective, X-linked, 1
Other names
3 names
Resolves to: tooth agenesis
- Also called
- hypodontiaselective tooth agenesistooth agenesis, selective