Pathway
Negative regulation of the PI3K/AKT network
The PI3K/AKT network is negatively regulated by phosphatases that dephosphorylate PIP3, thus hampering AKT activation.
REACT:R-HSA-199418Reactome
What the reference databases state
Statements
106 statements
106 statements · 1 reference database · Subject: Negative regulation of the PI3K/AKT network · Sources: Reactome
- AKT1 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- AKT2 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- AKT3 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- AREG participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- BDNF participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- BTC participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- CD19 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- CD28 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- CD80 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- CD86 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- EGF participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- EGFR participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
Show the remaining 94
- ERBB2 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- EREG participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- ESR1 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- ESR2 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- FGF1 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- FGF10 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- FGF16 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- FGF18 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- FGF19 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- FGF2 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- FGF20 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- FGF22 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- FGF23 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- FGF3 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- FGF4 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- FGF6 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- FGF7 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- FGF9 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- FGFR4 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- FLT3 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- FLT3LG participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- FRS2 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- FYN participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- GAB1 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- GAB2 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- HBEGF participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- HGF participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- IER3 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- IL1RL1 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- IL33 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- INS participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- INSR participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- IRAK1 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- IRAK4 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- IRS1 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- IRS2 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- KIT participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- KLB participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- LCK participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- MAPK1 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- MAPK3 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- MET participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- MYD88 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- NRG1 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- NRG2 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- NRG3 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- NRG4 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- NTF3 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- NTF4 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- NTRK2 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- NTRK3 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- PDGFB participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- PDGFRA participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- PDGFRB participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- PHLPP1 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- PHLPP2 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- PIK3AP1 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- PIK3CA participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- PIK3CB participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- PIK3CD participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- PIK3CG participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- PIK3R1 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- PIK3R2 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- PIK3R3 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- PIK3R5 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- PIK3R6 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- PIP4K2A participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- PIP4K2B participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- PIP4K2C participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- PIP5K1A participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- PIP5K1B participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- PIP5K1C participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- PPP2CA participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- PPP2CB participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- PPP2R1A participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- PPP2R1B participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- PPP2R5A participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- PPP2R5B participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- PPP2R5C participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- PPP2R5D participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- PPP2R5E participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- PTEN participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- PTPN11 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- RAC1 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- RAC2 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- RHOG participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- SRC participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- STRN participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- TGFA participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- THEM4 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- TRAF6 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- TRAT1 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- TRIB3 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only
- VAV1 participates in Negative regulation of the PI3K/AKT networkProteinReactome R-HSA-199418Inferred only