Pathway
GAB1 signalosome
GAB1 is recruited to the activated EGFR indirectly, through GRB2. GAB1 acts as an adaptor protein that enables formation of an active PIK3, through recruitment of PIK3 regulatory subunit PIK3R1 (also known as PI3Kp85), which subsequently recruits PIK3 catalytic subunit PIK3CA (also known as PI3Kp110). PIK3, in complex with EGFR, GRB2 and GAB1, catalyzes phosphorylation of PIP2 and its conversion to PIP3, which leads to the activation of the AKT signaling.
REACT:R-HSA-180292Reactome
What the reference databases state
Statements
15 statements
15 statements · 1 reference database · Subject: GAB1 signalosome · Sources: Reactome
- AREG participates in GAB1 signalosomeProteinReactome R-HSA-180292Inferred only
- BTC participates in GAB1 signalosomeProteinReactome R-HSA-180292Inferred only
- CSK participates in GAB1 signalosomeProteinReactome R-HSA-180292Inferred only
- EGF participates in GAB1 signalosomeProteinReactome R-HSA-180292Inferred only
- EGFR participates in GAB1 signalosomeProteinReactome R-HSA-180292Inferred only
- EREG participates in GAB1 signalosomeProteinReactome R-HSA-180292Inferred only
- GAB1 participates in GAB1 signalosomeProteinReactome R-HSA-180292Inferred only
- HBEGF participates in GAB1 signalosomeProteinReactome R-HSA-180292Inferred only
- PAG1 participates in GAB1 signalosomeProteinReactome R-HSA-180292Inferred only
- PIK3CA participates in GAB1 signalosomeProteinReactome R-HSA-180292Inferred only
- PIK3R1 participates in GAB1 signalosomeProteinReactome R-HSA-180292Inferred only
- PTPN11 participates in GAB1 signalosomeProteinReactome R-HSA-180292Inferred only
Show the remaining 3
- PXN participates in GAB1 signalosomeProteinReactome R-HSA-180292Inferred only
- SRC participates in GAB1 signalosomeProteinReactome R-HSA-180292Inferred only
- TGFA participates in GAB1 signalosomeProteinReactome R-HSA-180292Inferred only